Kojic Acid

Synonyms: 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one, Kojic acid, 501-30-4, 5-Hydroxy-2-hydroxymethyl-4-pyrone, Kojic acid (natural), 2-Hydroxymethyl-5-hydroxy-γ-pyrone

Kojic acid is a natural pyrone derivative produced by the fermentation of carbohydrate sources with Aspergillus oryzae. Its structure features a γ-pyrone ring with a hydroxyl group at C-5 and a hydroxymethyl group at C-2, enabling chelation of metal ions and interaction with enzymatic active sites. This mechanism underlies its primary function as a tyrosinase inhibitor, relevant to skin brightening and anti-pigmentation.

Commercially available as a white to off-white crystalline powder, kojic acid is standardized to ≥99.0% purity (HPLC). It is widely used in cosmetic, pharmaceutical, and research applications. In personal care, it is incorporated into serums, creams, and lotions targeting hyperpigmentation and uneven skin tone. In pharmaceuticals, it serves as a precursor for various synthetic intermediates.

Chemical Structure & Properties

Kojic acid (C₆H₆O₄) has a molecular weight of 142.11 g/mol and a melting point of 152-155°C. It is soluble in water and ethanol, slightly soluble in ether, and exhibits strong UV absorption. The compound is stable under normal storage conditions but may chelate with metal ions, affecting formulation stability.

Mechanism of Action

• Tyrosinase inhibition: Kojic acid chelates copper ions at the active site of tyrosinase, reversibly inhibiting the enzyme’s catalytic activity.
• Antioxidant activity: Scavenges free radicals and reduces oxidative stress in skin cells.
• Melanin synthesis suppression: Interferes with the polymerization of melanin precursors, leading to reduced pigmentation.
• Antimicrobial effects: Exhibits bacteriostatic and fungistatic properties against certain strains.

Quality Specifications (QC Tests)

Supply & Documentation

• Capacity: 20 metric tons per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 25 kg fiber drum with double PE liner, or as per customer requirement

Frequently Asked Questions

What is the MOQ for Kojic Acid?

Our standard MOQ is 25 kg. For trial orders, we can accommodate smaller quantities; please contact us for details.

What is the delivery time?

For stock items, delivery is 3-5 business days after order confirmation.

Can you provide a COA and samples?

Yes, we provide a COA for each batch. Samples are available upon request; please contact our sales team for arrangements.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.