Piperine

Từ đồng nghĩa: Piperine, 1-Piperoylpiperidine, (E,E)-1,5-Bis(4-methoxyphenyl)-1,4-pentadien-3-one, Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-

Piperine is an alkaloid found in black pepper (Piper nigrum) and long pepper (Piper longum), responsible for the pungent taste. Its structure features a piperidine ring linked to a piperic acid moiety via an amide bond. This unique chemical architecture underpins its bioactivity, particularly its ability to modulate drug metabolism and enhance bioavailability of other compounds.

As a commercial product, Piperine is available in high-purity grades (≥98%) produced through extraction and purification from natural sources or synthetic routes. It is standardized to ensure consistent potency and is widely used in dietary supplements, pharmaceuticals, and research to improve the absorption of nutrients and drugs.

In the B2B sector, Piperine serves as a key ingredient in formulations targeting enhanced bioavailability, metabolic support, and anti-inflammatory applications. Its well-documented interaction with drug-metabolizing enzymes makes it a valuable component in nutraceutical and pharmaceutical development.

Cấu trúc và tính chất hóa học

Piperine (C17H19NO3) is a lipophilic alkaloid with a molecular weight of 285.34 g/mol. It appears as white to off-white crystals, melts at 128-132°C, and is soluble in organic solvents like ethanol and chloroform but poorly soluble in water. The molecule contains a methylenedioxyphenyl group and a conjugated diene system, contributing to its UV absorption and reactivity.

Cơ chế tác dụng

• Inhibition of CYP3A4 and P-glycoprotein: Piperine reduces first-pass metabolism and efflux, increasing systemic exposure of co-administered drugs.
• Enhancement of nutrient absorption: It improves the bioavailability of curcumin, resveratrol, and beta-carotene by inhibiting intestinal glucuronidation.
• Hoạt tính chống viêm: Piperine modulates NF-κB and COX-2 pathways, reducing inflammatory mediators.
• Thermogenic effect: It may stimulate thermogenesis and inhibit adipocyte differentiation, supporting weight management.

Tiêu chuẩn chất lượng

Cung ứng và Tài liệu

• Công suất: 20 metric tons per year
• Thời gian thực hiện: 3-5 business days (stock items)
• Tài liệu hướng dẫn: COA, MSDS, TDS sẽ được cung cấp theo yêu cầu
• Bao bì: 25 kg fiber drums with double polyethylene bags, or as per customer requirements

Yêu cầu báo giá

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