Piperine

Synonyme: Piperine, 1-Piperoylpiperidine, (E,E)-1,5-Bis(4-methoxyphenyl)-1,4-pentadien-3-one, Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-

Piperine is an alkaloid found in black pepper (Piper nigrum) and long pepper (Piper longum), responsible for the pungent taste. Its structure features a piperidine ring linked to a piperic acid moiety via an amide bond. This unique chemical architecture underpins its bioactivity, particularly its ability to modulate drug metabolism and enhance bioavailability of other compounds.

As a commercial product, Piperine is available in high-purity grades (≥98%) produced through extraction and purification from natural sources or synthetic routes. It is standardized to ensure consistent potency and is widely used in dietary supplements, pharmaceuticals, and research to improve the absorption of nutrients and drugs.

In the B2B sector, Piperine serves as a key ingredient in formulations targeting enhanced bioavailability, metabolic support, and anti-inflammatory applications. Its well-documented interaction with drug-metabolizing enzymes makes it a valuable component in nutraceutical and pharmaceutical development.

Chemical Structure & Properties

Piperine (C17H19NO3) is a lipophilic alkaloid with a molecular weight of 285.34 g/mol. It appears as white to off-white crystals, melts at 128-132°C, and is soluble in organic solvents like ethanol and chloroform but poorly soluble in water. The molecule contains a methylenedioxyphenyl group and a conjugated diene system, contributing to its UV absorption and reactivity.

Mechanism of Action

• Inhibition of CYP3A4 and P-glycoprotein: Piperine reduces first-pass metabolism and efflux, increasing systemic exposure of co-administered drugs.
• Enhancement of nutrient absorption: It improves the bioavailability of curcumin, resveratrol, and beta-carotene by inhibiting intestinal glucuronidation.
• Anti-inflammatory activity: Piperine modulates NF-κB and COX-2 pathways, reducing inflammatory mediators.
• Thermogenic effect: It may stimulate thermogenesis and inhibit adipocyte differentiation, supporting weight management.

Quality Specifications

Supply & Documentation

• Capacity: 20 metric tons per year
• Lieferzeit: 3–5 Werktage (Lagerware)
• Dokumentation: COA, MSDS, TDS available upon request
• Verpackung: 25 kg fiber drums with double polyethylene bags, or as per customer requirements

Angebotsanfrage

• LyvBio GmbH. — E-Mail: info@lyvbio.com