| Название продукта | Nefiracetam |
| Synonyms | DM-9384; DMMPA; DZL-221; Translon; N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide; 2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)acetamide |
| Номер CAS | 77191-36-7 |
| Молекулярная формула | C₁₄H₁₈N₂O₂ |
| Молекулярная масса | 246.30 g/mol |
| Внешний вид | Кристаллический порошок от белого до небелого цвета |
| Анализ (ВЭЖХ) | ≥ 99.0% |
| Температура плавления | 125–129°C |
| Потери при сушке | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Тяжелые металлы | ≤ 10 ppm |
| Хранение | В прохладном, сухом, герметичном месте, защищенном от света |
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Nefiracetam (developmental code DM-9384) is a lipid-soluble nootropic compound belonging to the racetam family.
It is structurally distinct from other racetams due to the presence of a 2,6-dimethylphenyl group attached to the acetamide moiety.
This structural modification confers unique pharmacological properties, including GABAergic modulation (distinguishing it from most other racetams) and neuroprotective effects.
differentiator: Unlike most racetams that act primarily through glutamatergic (AMPA) modulation, Nefiracetam has demonstrated significant GABAergic activity, particularly at GABA-A receptors. This unique dual mechanism (GABAergic + glutamatergic) makes Nefiracetam particularly interesting for research into anxiety, neuroprotection, and cognitive disorders with an anxiety component.
Ключевые слова:Nefiracetam CAS 77191-36-7, DM-9384, DMMPA, Translon, GABA-A modulator, dual-mechanism nootropic, neuroprotection research, racetam family, calcium channel inhibitor, LyvBio Nefiracetam
Racetam Family Comparison:
| Compound | Solubility | Primary Mechanism | Unique Property |
|---|---|---|---|
| Piracetam | Water | AMPA (weak) | Parent compound |
| Оксирацетам | Water | AMPA | Learning acquisition |
| Aniracetam | Lipid | AMPA + nAChR | Anxiolytic |
| Nefiracetam | Lipid | AMPA + GABA-A | GABAergic modulation |
| Прамирацетам | Lipid | AMPA | Potent memory enhancement |
Important regulatory note: Nefiracetam is not FDA-approved for medical use in the United States. It has been investigated in clinical trials (including for Alzheimer’s disease and stroke recovery) but was not approved. It is available as a research chemical for laboratory use only. LyvBio supplies Nefiracetam strictly for research and development purposes.
Nefiracetam is a hydrophobic derivative of piracetam, which is generally considered to be a substance responsible for the discovery of calcium channels in the body and the indirect transfer of excitatory signaling substances as a partial agonist of calcium ion channels. Glycine binding site of NDMA receptor.
Through its effect on the cerebral cortex, nefiracetam can enhance cognitive abilities and prevent learning and memory impairment.
It does not possess muscarinic receptor agonist or antagonist properties, nor does it inhibit acetylcholinease activity.
Therefore, its anti-amnestic and memory-enhancing effects are achieved by improving the release of acetylcholine in the cerebral cortex.
| Продукт | CAS No. | Категория | Research Application |
|---|---|---|---|
| Piracetam | 7491-74-9 | Racetam | Memory research, comparative studies |
| Aniracetam | 72432-10-1 | Racetam | AMPA + anxiolytic research |
| Оксирацетам | 62613-82-5 | Racetam | Learning acquisition research |
| Прамирацетам | 68497-62-1 | Racetam | Potent memory enhancement |
| Phenylpiracetam | 77472-70-9 | Racetam | Stimulant + cognition research |
| Noopept (GVS-111) | 157115-85-0 | Dipeptide | Neuroprotection + cognition |
LyvBio Co., Ltd. is a GMP-certified supplier of high-purity Nefiracetam for research and development applications.
Возможности поставок:
Assay (HPLC): ≥99.0%
Форма: Crystalline powder
Ежемесячная производительность: 10+ kg
Большие объемы: 5g – 10kg
Время выполнения: 3-5 дней (образцы), 10-15 дней (опт)
Документация: COA, MSDS, TDS, HPLC chromatogram, stability data
Обеспечение качества:
HPLC purity with UV detection
Residual solvents tested (meets USP <467>)
Heavy metals tested (ICP-MS)
Structural confirmation (NMR upon request)
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