| Product Name | Nefiracetam |
| Synonyms | DM-9384; DMMPA; DZL-221; Translon; N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide; 2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)acetamide |
| CAS Number | 77191-36-7 |
| Molecular Formula | C₁₄H₁₈N₂O₂ |
| Molecular Weight | 246.30 g/mol |
| Appearance | White to off-white crystalline powder |
| Assay (HPLC) | ≥ 99.0% |
| Melting Point | 125–129°C |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm |
| Storage | Cool, dry, sealed, protected from light |
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Nefiracetam (developmental code DM-9384) is a lipid-soluble nootropic compound belonging to the racetam family.
It is structurally distinct from other racetams due to the presence of a 2,6-dimethylphenyl group attached to the acetamide moiety.
This structural modification confers unique pharmacological properties, including GABAergic modulation (distinguishing it from most other racetams) and neuroprotective effects.
differentiator: Unlike most racetams that act primarily through glutamatergic (AMPA) modulation, Nefiracetam has demonstrated significant GABAergic activity, particularly at GABA-A receptors. This unique dual mechanism (GABAergic + glutamatergic) makes Nefiracetam particularly interesting for research into anxiety, neuroprotection, and cognitive disorders with an anxiety component.
Keywords:Nefiracetam CAS 77191-36-7, DM-9384, DMMPA, Translon, GABA-A modulator, dual-mechanism nootropic, neuroprotection research, racetam family, calcium channel inhibitor, LyvBio Nefiracetam
Racetam Family Comparison:
| Compound | Solubility | Primary Mechanism | Unique Property |
|---|---|---|---|
| Piracetam | Water | AMPA (weak) | Parent compound |
| Oxiracetam | Water | AMPA | Learning acquisition |
| Aniracetam | Lipid | AMPA + nAChR | Anxiolytic |
| Nefiracetam | Lipid | AMPA + GABA-A | GABAergic modulation |
| Pramiracetam | Lipid | AMPA | Potent memory enhancement |
Important regulatory note: Nefiracetam is not FDA-approved for medical use in the United States. It has been investigated in clinical trials (including for Alzheimer’s disease and stroke recovery) but was not approved. It is available as a research chemical for laboratory use only. LyvBio supplies Nefiracetam strictly for research and development purposes.
Nefiracetam is a hydrophobic derivative of piracetam, which is generally considered to be a substance responsible for the discovery of calcium channels in the body and the indirect transfer of excitatory signaling substances as a partial agonist of calcium ion channels. Glycine binding site of NDMA receptor.
Through its effect on the cerebral cortex, nefiracetam can enhance cognitive abilities and prevent learning and memory impairment.
It does not possess muscarinic receptor agonist or antagonist properties, nor does it inhibit acetylcholinease activity.
Therefore, its anti-amnestic and memory-enhancing effects are achieved by improving the release of acetylcholine in the cerebral cortex.
| Product | CAS No. | Category | Research Application |
|---|---|---|---|
| Piracetam | 7491-74-9 | Racetam | Memory research, comparative studies |
| Aniracetam | 72432-10-1 | Racetam | AMPA + anxiolytic research |
| Oxiracetam | 62613-82-5 | Racetam | Learning acquisition research |
| Pramiracetam | 68497-62-1 | Racetam | Potent memory enhancement |
| Phenylpiracetam | 77472-70-9 | Racetam | Stimulant + cognition research |
| Noopept (GVS-111) | 157115-85-0 | Dipeptide | Neuroprotection + cognition |
LyvBio Co., Ltd. is a GMP-certified supplier of high-purity Nefiracetam for research and development applications.
Supply capabilities:
Assay (HPLC): ≥99.0%
Form: Crystalline powder
Monthly capacity: 10+ kg
Bulk quantities: 5g – 10kg
Lead time: 3–5 days (samples), 10–15 days (bulk)
Documentation: COA, MSDS, TDS, HPLC chromatogram, stability data
Quality assurance:
HPLC purity with UV detection
Residual solvents tested (meets USP <467>)
Heavy metals tested (ICP-MS)
Structural confirmation (NMR upon request)
📧 Email: info@lyvbio.com
🌐 Website: https://www.lyvbio.com
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