| Product Name | Blonanserin |
| CAS Number | 132810-10-7 |
| Molecular Formula | C₂₃H₃₀FN₃ |
| Molecular Weight | 367.50 g/mol |
| Appearance | White to off-white crystalline powder |
| Assay (HPLC) | ≥ 99.0% |
| Melting Point | 123–126°C |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm |
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Blonanserin (development code AD-5423; brand name Lonasen®) is a second-generation atypical antipsychotic developed by Dainippon Sumitomo Pharma. It is approved in Japan and China for the treatment of schizophrenia. Unlike many atypical antipsychotics that act on multiple receptor targets, blonanserin has a relatively selective receptor profile, primarily antagonizing dopamine D₂/D₃ and serotonin 5-HT₂A receptors.
differentiator: Blonanserin has high selectivity for D₂/D₃ receptors over D₁ receptors and low affinity for histamine H₁, muscarinic M₁, and α₁-adrenergic receptors. This translates to a favorable side effect profile with lower risks of weight gain, sedation, and metabolic syndrome compared to other atypical antipsychotics (e.g., olanzapine, quetiapine, risperidone).
Synonyms:
AD-5423
Lonasen
Bunanserin
2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
LyvBio Co., Ltd. is a supplier of high-purity Blonanserin for pharmaceutical research and development.
Supply capabilities:
Purity: ≥99.0% (HPLC)
Monthly capacity: 20+ kg
Bulk quantities: 10g – 50kg
Lead time: 3–5 days (samples), 10–15 days (bulk)
Documentation: COA, HPLC chromatogram, stability data
📧 Inquiries: info@lyvbio.com
| Parameter | Specification | Test Method |
|---|---|---|
| Assay (HPLC) | ≥ 99.0% | HPLC |
| Appearance | White to off-white crystalline powder | Visual |
| Identification | HPLC retention time, IR | HPLC/IR |
| Melting Point | 123–126°C | USP <741> |
| Loss on Drying | ≤ 0.5% | USP <731> |
| Residue on Ignition | ≤ 0.1% | USP <281> |
| Heavy Metals | ≤ 10 ppm | ICP-MS |
| Related Substances | Single impurity ≤ 0.2%; Total ≤ 1.0% | HPLC-UV |
| Residual Solvents | Meet USP <467> | GC |
| Product | CAS No. | Category |
|---|---|---|
| Olanzapine | 132539-06-1 | Atypical antipsychotic |
| Quetiapine Fumarate | 111974-72-2 | Atypical antipsychotic |
| Risperidone | 106266-06-2 | Atypical antipsychotic |
| Aripiprazole | 129722-12-9 | Atypical antipsychotic |
| Paliperidone | 144598-75-4 | Atypical antipsychotic |
| Lurasidone HCl | 367514-88-3 | Atypical antipsychotic |
📧 Email: info@lyvbio.com
🌐 Website: https://www.lyvbio.com
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