| Product Name | MYK-461 |
|---|---|
| CAS Number | 1642288-47-8 |
| Molecular Formula | C₁₈H₁₆FN₃O₃S |
| Molecular Weight | 373.40 g/mol |
| Appearance | White to off-white powder |
| Assay (HPLC) | ≥ 98.0% |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm |
| Storage | Store in a cool, dry place, protected from light |
| Solubility | Soluble in DMSO, DMF; slightly soluble in ethanol |
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Mavacamten (development code MYK-461) is a first-in-class, selective, allosteric inhibitor of cardiac myosin. It is the first pharmacological agent approved to target the underlying pathophysiology of hypertrophic cardiomyopathy (HCM) —a condition characterized by excessive cardiac muscle contraction, hypercontractility, and impaired relaxation (diastolic dysfunction).
Mechanism of action: Mavacamten binds selectively to the catalytic domain of cardiac myosin ATPase, reducing the number of myosin heads available for actin binding. This decreases cardiac contractility, reduces left ventricular outflow tract (LVOT) gradient, and improves diastolic filling.
Chemical structure highlights:
Small molecule (MW 273.33)
Allosteric modulator (not ATP-competitive)
Highly selective for cardiac myosin (vs. smooth muscle or skeletal myosin)
Oral bioavailability (well-absorbed)
Synonym：MYK-461(SAR-439152);SAR439152;SAR439152;SAR-439152;SAR-439152;SAR439152;SAR439152;MYK-461;MYK461;MYK461;MAVACAMTEN;MYK-461-Mavacamten|SAR439152;Mavacamten(MYK-461;2,4(1H,3H)-Pyrimidinedione,3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-
| Parameter | Specification |
|---|---|
| MYK‑461 Content (HPLC) | ≥ 98.0% |
| Identification | IR / MS / NMR conforms to reference |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals (as Pb) | ≤ 10 ppm |
| Arsenic (As) | ≤ 1 ppm |
| Residual Solvents | Meets USP requirements |
Source: Synthetic chemical synthesis
Standardization: ≥98.0% MYK-461 (HPLC)
Forms: White to off‑white powder
Applications: Pharmaceutical research, formulation development, analytical standards, preclinical studies
Monthly capacity: 5+ kg
Lead time: 3–5 days (samples), 10–15 days (bulk)
Documentation: COA, MSDS,HPLC chromatogram, stability data, NMR (upon request)
Packaging: 1 kg, 5 kg, 10 kg, 25 kg (double‑layer PE bag inside, fiber drum outside)
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