| Nombre del producto | Nefiracetam |
| Sinónimos | DM-9384; DMMPA; DZL-221; Translon; N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide; 2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)acetamide |
| Número CAS | 77191-36-7 |
| Fórmula molecular | C₁₄H₁₈N₂O₂ |
| Peso molecular | 246.30 g/mol |
| Apariencia | Polvo cristalino de color blanco a blanquecino |
| Ensayo (HPLC) | ≥ 99,01 TP3T |
| Punto de fusión | 125–129°C |
| Pérdida por secado | ≤ 0,51 TP3T |
| Residuo tras la combustión | ≤ 0,11 TP3T |
| Metales pesados | ≤ 10 ppm |
| Almacenamiento | En un lugar fresco, seco, hermético y protegido de la luz |
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Nefiracetam (developmental code DM-9384) is a lipid-soluble nootropic compound belonging to the racetam family.
It is structurally distinct from other racetams due to the presence of a 2,6-dimethylphenyl group attached to the acetamide moiety.
This structural modification confers unique pharmacological properties, including GABAergic modulation (distinguishing it from most other racetams) and neuroprotective effects.
elemento diferenciador: Unlike most racetams that act primarily through glutamatergic (AMPA) modulation, Nefiracetam has demonstrated significant GABAergic activity, particularly at GABA-A receptors. This unique dual mechanism (GABAergic + glutamatergic) makes Nefiracetam particularly interesting for research into anxiety, neuroprotection, and cognitive disorders with an anxiety component.
Palabras clave:Nefiracetam CAS 77191-36-7, DM-9384, DMMPA, Translon, GABA-A modulator, dual-mechanism nootropic, neuroprotection research, racetam family, calcium channel inhibitor, LyvBio Nefiracetam
Racetam Family Comparison:
| Compuesto | Solubilidad | Primary Mechanism | Unique Property |
|---|---|---|---|
| Piracetam | Water | AMPA (weak) | Compuesto original |
| Oxiracetam | Water | AMPA | Learning acquisition |
| Aniracetam | Lipid | AMPA + nAChR | Anxiolytic |
| Nefiracetam | Lipid | AMPA + GABA-A | GABAergic modulation |
| Pramiracetam | Lipid | AMPA | Potent memory enhancement |
Important regulatory note: Nefiracetam is not FDA-approved for medical use in the United States. It has been investigated in clinical trials (including for Alzheimer’s disease and stroke recovery) but was not approved. It is available as a research chemical for laboratory use only. LyvBio supplies Nefiracetam strictly for research and development purposes.
Nefiracetam is a hydrophobic derivative of piracetam, which is generally considered to be a substance responsible for the discovery of calcium channels in the body and the indirect transfer of excitatory signaling substances as a partial agonist of calcium ion channels. Glycine binding site of NDMA receptor.
Through its effect on the cerebral cortex, nefiracetam can enhance cognitive abilities and prevent learning and memory impairment.
It does not possess muscarinic receptor agonist or antagonist properties, nor does it inhibit acetylcholinease activity.
Therefore, its anti-amnestic and memory-enhancing effects are achieved by improving the release of acetylcholine in the cerebral cortex.
| Producto | N.º CAS. | Categoría | Solicitud de investigación |
|---|---|---|---|
| Piracetam | 7491-74-9 | Racetam | Investigación sobre la memoria, estudios comparativos |
| Aniracetam | 72432-10-1 | Racetam | AMPA + anxiolytic research |
| Oxiracetam | 62613-82-5 | Racetam | Learning acquisition research |
| Pramiracetam | 68497-62-1 | Racetam | Potent memory enhancement |
| Fenilpiracetam | 77472-70-9 | Racetam | Investigación sobre estimulantes y cognición |
| Noopept (GVS-111) | 157115-85-0 | Dipéptido | Neuroprotection + cognition |
LyvBio S.L. es un proveedor con certificación GMP de oxiracetam de alta pureza para aplicaciones de investigación y desarrollo.
Capacidad de suministro:
Ensayo (HPLC): ≥99,01 TP3T
Formulario: Polvo cristalino
Capacidad mensual: Más de 10 kg
Cantidades al por mayor: 5g – 10kg
Plazo de entrega: 3-5 días (muestras), 10-15 días (a granel)
Documentación: COA, ficha de datos de seguridad (FDS), ficha técnica del producto (FTP), cromatograma de HPLC, datos de estabilidad
Control de calidad:
Pureza determinada por HPLC con detección UV
Se han analizado los disolventes residuales (cumple con la norma USP )
Metales pesados analizados (ICP-MS)
Confirmación estructural (RMN previa solicitud)
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