Baicalein

Baicalein

Số CAS: 491-67-8
Nguồn gốc thực vật: Chiết xuất từ cây Scutellaria baicalensis
Phương pháp thử nghiệm: HPLC
Hình thức: Yellow to light yellow crystalline powder
Thông số kỹ thuật: 98% – 99% (standardized)
Công thức phân tử: C15H10O5
Khối lượng phân tử: 270.24
Ứng dụng: Neuroprotection & Brain Health,Skincare & Cosmeceutical
Từ đồng nghĩa: BAICALEIN(SH)NOW RG GRADE;Baicalein, monohydrate,Baicalein 98%

What is Baicalein?

Baicalein is one of the major bioactive flavonoids extracted from the roots of Scutellaria baicalensis (Chinese skullcap), a perennial plant used in Traditional Chinese Medicine for centuries. Unlike its glycoside form baicalin, baicalein is the aglycone (non-sugar) form, which exhibits higher lipophilicity and superior bioavailability.

This structural difference allows baicalein to cross the blood-brain barrier (BBB) more effectively, making it particularly valuable for neuroprotective applications.

Từ đồng nghĩa: Baicalein, 5,6,7-Trihydroxyflavone, Baicalein 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one, NSC 83206, Flavone, 5,6,7-trihydroxy-, 5,6,7-Trihydroxy-2-phenylchromen-4-one, 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one

buy Baicalein

Scutellaria baicalenis -5% Baicalin

Mechanisms of Action (MOA)

Lộ trình Tác dụng
12-LOX inhibition Blocks leukotriene synthesis – potent anti-inflammatory
Xanthine oxidase inhibition Reduces uric acid production
Nrf2 activation Enhances antioxidant defense enzymes
NF-κB suppression Downregulates pro-inflammatory cytokines (TNF-α, IL-6, IL-1β)
GABA-A receptor modulation Anxiolytic and anticonvulsant properties
Ferroptosis inhibition Protects neurons from iron-dependent cell death

Ứng dụng

1. Neuroprotection & Brain Health

  • Parkinson’s disease – Protects dopaminergic neurons via 12-LOX inhibition and ferroptosis blockade
  • Alzheimer’s disease – Reduces β-amyloid aggregation and tau hyperphosphorylation
  • Cerebral ischemia (stroke) – Decreases infarct volume and oxidative damage
  • Anxiety & depression – GABAergic activity without sedation

2. Anti-Inflammatory & Immune Modulation

  • Arthritis – Suppresses joint inflammation
  • Inflammatory bowel disease (IBD) – Reduces colonic inflammation
  • Allergic conditions – Inhibits mast cell degranulation

3. Skincare & Cosmeceutical

  • UV protection – Absorbs UVB and reduces photoaging
  • Anti-acne – Antimicrobial against Cutibacterium acnes
  • Atopic dermatitis – Calms inflammation and pruritus
  • Wound healing – Promotes fibroblast proliferation and collagen synthesis
  • Anti-pigmentation – Inhibits tyrosinase and melanin transfer

4. Metabolic Health

  • Uric acid reduction – Xanthine oxidase inhibition (comparable to allopurinol)
  • Liver protection – Reduces hepatic steatosis and fibrosis
  • Cardioprotection – Lowers oxidative stress in cardiac tissue

Available Grades:

Chất lượng dược phẩm – For oral capsules, tablets, injections (research)
Cosmetic Grade – For serums, creams, lotions

Nutraceutical Grade – For dietary supplements

Nguồn gốc & Độ tinh khiết

  • NguồnScutellaria baicalensis root

  • Tiêu chuẩn hóa: ≥85.0% baicalein (HPLC)

  • Biểu mẫu: Yellow crystalline powder

  • Ứng dụng: Research applications (neuroprotection, cardioprotection, cancer research), dietary supplements (cognitive health, immune support, inflammation), functional foods, cosmetics.

Những lợi ích khi hợp tác với Công ty TNHH LyvBio.

At LyvBio Co., Ltd. , we provide high-purity baicalein with:

  • Botanical authenticity – 100% Scutellaria baicalensis root origin, HPLC fingerprinted
  • Full documentation – COA, MSDS, MOA, flow chart, stability data, allergen statement
  • Third-party testing – Heavy metals, residual solvents, pesticides, microbials
  • Flexible packaging – 100g, 500g, 1kg, 5kg, 25kg drums
  • Lead time – Samples: 3–5 days; Bulk orders: 10–15 working days

 Câu hỏi thường gặp

Q: What is the difference between baicalein and baicalin?
A: Baicalin is the 7-O-glucuronide glycoside form; baicalein is the aglycone. Baicalein has higher lipophilicity and better brain penetration, while baicalin is more water-soluble.

Q: What is the recommended oral dosage for supplements?
A: Clinical studies typically use 100–500 mg daily for neuroprotection. Consult your R&D team for formulation-specific dosing.

Q: Is baicalein suitable for topical use?
A: Yes. It is stable and effective in serums, creams, and lotions at 0.1–1%. The yellow color may be a consideration for clear gels.

Q: Do you provide Kosher/Halal certification?
A: Yes. Available upon request for bulk orders.

Hỏi: Số lượng đặt hàng tối thiểu (MOQ) của quý công ty là bao nhiêu?
A: 100g for sample orders; 1kg for trial production; volume discounts for 25kg+.

Liên hệ với Công ty TNHH LyvBio.
Looking for a reliable baicalein supplier for your next formulation?
📧 Email: info@lyvbio.com

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