Baicalein

Baicalein

CAS No: 491-67-8
Botanical source: Scutellaria baicalensis extract
Test Method: HPLC
Appearance: Yellow to light yellow crystalline powder
Specifications: 98% – 99% (standardized)
Molecular Formula: C15H10O5
Molecular Weight: 270.24
Applications: Neuroprotection & Brain Health,Skincare & Cosmeceutical
Synonym: BAICALEIN(SH)NOW RG GRADE;Baicalein, monohydrate,Baicalein 98%

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What is Baicalein?

Baicalein is one of the major bioactive flavonoids extracted from the roots of Scutellaria baicalensis (Chinese skullcap), a perennial plant used in Traditional Chinese Medicine for centuries. Unlike its glycoside form baicalin, baicalein is the aglycone (non-sugar) form, which exhibits higher lipophilicity and superior bioavailability.

This structural difference allows baicalein to cross the blood-brain barrier (BBB) more effectively, making it particularly valuable for neuroprotective applications.

Mechanisms of Action (MOA)

Pathway Effect
12-LOX inhibition Blocks leukotriene synthesis – potent anti-inflammatory
Xanthine oxidase inhibition Reduces uric acid production
Nrf2 activation Enhances antioxidant defense enzymes
NF-κB suppression Downregulates pro-inflammatory cytokines (TNF-α, IL-6, IL-1β)
GABA-A receptor modulation Anxiolytic and anticonvulsant properties
Ferroptosis inhibition Protects neurons from iron-dependent cell death

Applications

1. Neuroprotection & Brain Health

  • Parkinson’s disease – Protects dopaminergic neurons via 12-LOX inhibition and ferroptosis blockade
  • Alzheimer’s disease – Reduces β-amyloid aggregation and tau hyperphosphorylation
  • Cerebral ischemia (stroke) – Decreases infarct volume and oxidative damage
  • Anxiety & depression – GABAergic activity without sedation

2. Anti-Inflammatory & Immune Modulation

  • Arthritis – Suppresses joint inflammation
  • Inflammatory bowel disease (IBD) – Reduces colonic inflammation
  • Allergic conditions – Inhibits mast cell degranulation

3. Skincare & Cosmeceutical

  • UV protection – Absorbs UVB and reduces photoaging
  • Anti-acne – Antimicrobial against Cutibacterium acnes
  • Atopic dermatitis – Calms inflammation and pruritus
  • Wound healing – Promotes fibroblast proliferation and collagen synthesis
  • Anti-pigmentation – Inhibits tyrosinase and melanin transfer

4. Metabolic Health

  • Uric acid reduction – Xanthine oxidase inhibition (comparable to allopurinol)
  • Liver protection – Reduces hepatic steatosis and fibrosis
  • Cardioprotection – Lowers oxidative stress in cardiac tissue

Available Grades:

Pharmaceutical Grade – For oral capsules, tablets, injections (research)
Cosmetic Grade – For serums, creams, lotions

Nutraceutical Grade – For dietary supplements

Advantages of Sourcing from LyvBio Co., Ltd.

At LyvBio Co., Ltd. , we provide high-purity baicalein with:

  • Botanical authenticity – 100% Scutellaria baicalensis root origin, HPLC fingerprinted
  • Full documentation – COA, MSDS, MOA, flow chart, stability data, allergen statement
  • Third-party testing – Heavy metals, residual solvents, pesticides, microbials
  • Flexible packaging – 100g, 500g, 1kg, 5kg, 25kg drums
  • Lead time – Samples: 3–5 days; Bulk orders: 10–15 working days

 FAQs

Q: What is the difference between baicalein and baicalin?
A: Baicalin is the 7-O-glucuronide glycoside form; baicalein is the aglycone. Baicalein has higher lipophilicity and better brain penetration, while baicalin is more water-soluble.

Q: What is the recommended oral dosage for supplements?
A: Clinical studies typically use 100–500 mg daily for neuroprotection. Consult your R&D team for formulation-specific dosing.

Q: Is baicalein suitable for topical use?
A: Yes. It is stable and effective in serums, creams, and lotions at 0.1–1%. The yellow color may be a consideration for clear gels.

Q: Do you provide Kosher/Halal certification?
A: Yes. Available upon request for bulk orders.

Q: What is your MOQ?
A: 100g for sample orders; 1kg for trial production; volume discounts for 25kg+.

Contact LyvBio Co., Ltd.
Looking for a reliable baicalein supplier for your next formulation?
📧 Email: info@lyvbio.com
🌐 Website: https://www.lyvbio.com

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