What is Baicalein?
Baicalein is one of the major bioactive flavonoids extracted from the roots of Scutellaria baicalensis (Chinese skullcap), a perennial plant used in Traditional Chinese Medicine for centuries. Unlike its glycoside form baicalin, baicalein is the aglycone (non-sugar) form, which exhibits higher lipophilicity and superior bioavailability.
This structural difference allows baicalein to cross the blood-brain barrier (BBB) more effectively, making it particularly valuable for neuroprotective applications.

Mechanisms of Action (MOA)
| Pathway |
Effect |
| 12-LOX inhibition |
Blocks leukotriene synthesis – potent anti-inflammatory |
| Xanthine oxidase inhibition |
Reduces uric acid production |
| Nrf2 activation |
Enhances antioxidant defense enzymes |
| NF-κB suppression |
Downregulates pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) |
| GABA-A receptor modulation |
Anxiolytic and anticonvulsant properties |
| Ferroptosis inhibition |
Protects neurons from iron-dependent cell death |
Applications
1. Neuroprotection & Brain Health
- Parkinson’s disease – Protects dopaminergic neurons via 12-LOX inhibition and ferroptosis blockade
- Alzheimer’s disease – Reduces β-amyloid aggregation and tau hyperphosphorylation
- Cerebral ischemia (stroke) – Decreases infarct volume and oxidative damage
- Anxiety & depression – GABAergic activity without sedation
2. Anti-Inflammatory & Immune Modulation
- Arthritis – Suppresses joint inflammation
- Inflammatory bowel disease (IBD) – Reduces colonic inflammation
- Allergic conditions – Inhibits mast cell degranulation
3. Skincare & Cosmeceutical
- UV protection – Absorbs UVB and reduces photoaging
- Anti-acne – Antimicrobial against Cutibacterium acnes
- Atopic dermatitis – Calms inflammation and pruritus
- Wound healing – Promotes fibroblast proliferation and collagen synthesis
- Anti-pigmentation – Inhibits tyrosinase and melanin transfer
4. Metabolic Health
- Uric acid reduction – Xanthine oxidase inhibition (comparable to allopurinol)
- Liver protection – Reduces hepatic steatosis and fibrosis
- Cardioprotection – Lowers oxidative stress in cardiac tissue
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Scutellaria baicalensis extract 20:1
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98% Baicalein CAS 491-67-8
Available Grades:
Pharmaceutical Grade – For oral capsules, tablets, injections (research)
Cosmetic Grade – For serums, creams, lotions
Nutraceutical Grade – For dietary supplements
Advantages of Sourcing from LyvBio Co., Ltd.
At LyvBio Co., Ltd. , we provide high-purity baicalein with:
- Botanical authenticity – 100% Scutellaria baicalensis root origin, HPLC fingerprinted
- Full documentation – COA, MSDS, MOA, flow chart, stability data, allergen statement
- Third-party testing – Heavy metals, residual solvents, pesticides, microbials
- Flexible packaging – 100g, 500g, 1kg, 5kg, 25kg drums
- Lead time – Samples: 3–5 days; Bulk orders: 10–15 working days
FAQs
Q: What is the difference between baicalein and baicalin?
A: Baicalin is the 7-O-glucuronide glycoside form; baicalein is the aglycone. Baicalein has higher lipophilicity and better brain penetration, while baicalin is more water-soluble.
Q: What is the recommended oral dosage for supplements?
A: Clinical studies typically use 100–500 mg daily for neuroprotection. Consult your R&D team for formulation-specific dosing.
Q: Is baicalein suitable for topical use?
A: Yes. It is stable and effective in serums, creams, and lotions at 0.1–1%. The yellow color may be a consideration for clear gels.
Q: Do you provide Kosher/Halal certification?
A: Yes. Available upon request for bulk orders.
Q: What is your MOQ?
A: 100g for sample orders; 1kg for trial production; volume discounts for 25kg+.
Contact LyvBio Co., Ltd.
Looking for a reliable baicalein supplier for your next formulation?
📧 Email: info@lyvbio.com
🌐 Website: https://www.lyvbio.com
Application information coming soon.
Certification information coming soon.