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Baicalein is one of the major bioactive flavonoids extracted from the roots of Scutellaria baicalensis (Chinese skullcap), a perennial plant used in Traditional Chinese Medicine for centuries. Unlike its glycoside form baicalin, baicalein is the aglycone (non-sugar) form, which exhibits higher lipophilicity and superior bioavailability.
This structural difference allows baicalein to cross the blood-brain barrier (BBB) more effectively, making it particularly valuable for neuroprotective applications.

| Pathway | Effect |
|---|---|
| 12-LOX inhibition | Blocks leukotriene synthesis – potent anti-inflammatory |
| Xanthine oxidase inhibition | Reduces uric acid production |
| Nrf2 activation | Enhances antioxidant defense enzymes |
| NF-κB suppression | Downregulates pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) |
| GABA-A receptor modulation | Anxiolytic and anticonvulsant properties |
| Ferroptosis inhibition | Protects neurons from iron-dependent cell death |
Nutraceutical Grade – For dietary supplements
At LyvBio Co., Ltd. , we provide high-purity baicalein with:
Q: What is the difference between baicalein and baicalin?
A: Baicalin is the 7-O-glucuronide glycoside form; baicalein is the aglycone. Baicalein has higher lipophilicity and better brain penetration, while baicalin is more water-soluble.
Q: What is the recommended oral dosage for supplements?
A: Clinical studies typically use 100–500 mg daily for neuroprotection. Consult your R&D team for formulation-specific dosing.
Q: Is baicalein suitable for topical use?
A: Yes. It is stable and effective in serums, creams, and lotions at 0.1–1%. The yellow color may be a consideration for clear gels.
Q: Do you provide Kosher/Halal certification?
A: Yes. Available upon request for bulk orders.
Hỏi: Số lượng đặt hàng tối thiểu (MOQ) của quý công ty là bao nhiêu?
A: 100g for sample orders; 1kg for trial production; volume discounts for 25kg+.
280 Phố Chính, Tây An, Thiểm Tây, Trung Quốc