Lamotrigine

Synonyms :Lamictal, BW-430C, 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine, Lamotrigine base, Lamotrigine USP

Lamotrigine is a phenyltriazine derivative that functions as an anticonvulsant and mood-stabilizing agent. It is primarily used in the management of epilepsy and bipolar disorder, where it helps to stabilize neuronal membranes by blocking voltage-sensitive sodium channels and inhibiting the release of excitatory neurotransmitters, particularly glutamate. This mechanism of action contributes to its efficacy in reducing seizure frequency and preventing mood episodes.

As a pharmaceutical intermediate, lamotrigine is a key active pharmaceutical ingredient (API) in the production of antiepileptic and psychiatric medications. Its well-characterized profile and established therapeutic benefits make it a valuable compound for both research and commercial applications.

Функция

• Anticonvulsant Activity: Inhibits voltage-gated sodium channels, stabilizing presynaptic neuronal membranes and reducing abnormal electrical discharges in the brain.
• Glutamate Release Inhibition: Modulates the release of excitatory amino acids, particularly glutamate, thereby dampening excitatory neurotransmission and preventing seizure propagation.
• Mood Stabilization: Exhibits efficacy in bipolar disorder by prolonging the time to depressive and manic episodes, likely through similar ion channel modulation and neurotransmitter regulation.
• Neuroprotective Effects: Demonstrates potential neuroprotective properties in models of ischemia and excitotoxicity, supporting its use in neurological conditions.

Источник и чистота

• Источник: Synthetic compound produced via chemical synthesis, with high purity suitable for pharmaceutical use.
• Стандартизация: Conforms to USP/EP specifications; assay (HPLC) 98.0% – 101.0% on dried basis.
• Формы: Available as a crystalline powder, typically in bulk quantities for formulation or further processing.
• Приложения: Used as an API in tablets, oral suspensions, and other dosage forms for epilepsy and bipolar disorder; also employed in research and development.

Документация и поставки

• Документация: сертификат соответствия (COA), паспорт безопасности материала (MSDS), техническое описание продукта (TDS)
• Срок выполнения заказа: 7-15 days after order confirmation, depending on quantity and destination.
• Упаковка: Supplied in double polyethylene bags inside fiber drums or as per customer request; net weight 25 kg per drum.

Запрос Цитировать

• Наш адрес: 280 Main Street, Сиань, провинция Шэньси, Китай
• LyvBio Co., Ltd. — Электронная почта: info@lyvbio.com

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