Hexapeptide-10

Синонимы: Hexapeptide-10, H-10, Palmitoyl Hexapeptide-10, N-Acetyl Hexapeptide-10

Hexapeptide-10 is a synthetic peptide composed of six amino acids, with the sequence Tyr-D-Ala-Gly-Phe-Leu-Arg. It is a structural analog of the endogenous neuropeptide met-enkephalin, designed to modulate neurogenic inflammation and sensory nerve activity in the skin. The D-alanine residue at position 2 enhances stability against enzymatic degradation, while the C-terminal arginine contributes to its hydrophilic character and receptor interaction.

As a cosmetic ingredient, Hexapeptide-10 is typically supplied as a white to off-white powder with high purity, often stabilized with palmitoyl or acetyl groups to improve skin penetration and half-life. It is produced via solid-phase peptide synthesis and purified by HPLC to ≥95%. The peptide is soluble in water and polar organic solvents, making it suitable for incorporation into a range of topical formulations.

In the personal care industry, Hexapeptide-10 is used in anti-aging and soothing products targeting sensitive or reactive skin. It is believed to reduce the release of pro-inflammatory neuropeptides such as substance P and CGRP, thereby calming the skin and reducing redness and discomfort. Its mechanism of action and good safety profile make it a valuable active for products aimed at neurocosmetic benefits.

Chemical Structure & Properties

Hexapeptide-10 features a linear six-amino acid chain with a molecular weight of approximately 762.9 g/mol. The presence of D-alanine confers resistance to peptidases, while the arginine residue provides a positive charge at physiological pH, enhancing interaction with negatively charged cell membranes. The peptide is highly soluble in water and exhibits good stability when stored under recommended conditions.

Механизм действия

• Neuropeptide modulation: Hexapeptide-10 acts as a competitive antagonist at neurokinin-1 receptors, blocking the binding of substance P and reducing neurogenic inflammation.
• Downregulation of CGRP: It decreases the release of calcitonin gene-related peptide from sensory neurons, alleviating redness and irritation.
• Skin barrier support: By calming sensory nerve overactivity, it indirectly supports barrier recovery and reduces sensitivity.
• Anti-aging effects: Modulation of neurogenic inflammation may help prevent collagen degradation and premature aging linked to chronic stress.

Quality Specifications

Supply & Documentation

• Capacity: 100 kg per month
• Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 g, 5 g, 10 g, 50 g, 100 g in amber glass vials or as customized

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