Hexapeptide-10

Synonyms: Hexapeptide-10, H-10, Palmitoyl Hexapeptide-10, N-Acetyl Hexapeptide-10

Hexapeptide-10 is a synthetic peptide composed of six amino acids, with the sequence Tyr-D-Ala-Gly-Phe-Leu-Arg. It is a structural analog of the endogenous neuropeptide met-enkephalin, designed to modulate neurogenic inflammation and sensory nerve activity in the skin. The D-alanine residue at position 2 enhances stability against enzymatic degradation, while the C-terminal arginine contributes to its hydrophilic character and receptor interaction.

As a cosmetic ingredient, Hexapeptide-10 is typically supplied as a white to off-white powder with high purity, often stabilized with palmitoyl or acetyl groups to improve skin penetration and half-life. It is produced via solid-phase peptide synthesis and purified by HPLC to ≥95%. The peptide is soluble in water and polar organic solvents, making it suitable for incorporation into a range of topical formulations.

In the personal care industry, Hexapeptide-10 is used in anti-aging and soothing products targeting sensitive or reactive skin. It is believed to reduce the release of pro-inflammatory neuropeptides such as substance P and CGRP, thereby calming the skin and reducing redness and discomfort. Its mechanism of action and good safety profile make it a valuable active for products aimed at neurocosmetic benefits.

Chemical Structure & Properties

Hexapeptide-10 features a linear six-amino acid chain with a molecular weight of approximately 762.9 g/mol. The presence of D-alanine confers resistance to peptidases, while the arginine residue provides a positive charge at physiological pH, enhancing interaction with negatively charged cell membranes. The peptide is highly soluble in water and exhibits good stability when stored under recommended conditions.

Mechanism of Action

• Neuropeptide modulation: Hexapeptide-10 acts as a competitive antagonist at neurokinin-1 receptors, blocking the binding of substance P and reducing neurogenic inflammation.
• Downregulation of CGRP: It decreases the release of calcitonin gene-related peptide from sensory neurons, alleviating redness and irritation.
• Skin barrier support: By calming sensory nerve overactivity, it indirectly supports barrier recovery and reduces sensitivity.
• Anti-aging effects: Modulation of neurogenic inflammation may help prevent collagen degradation and premature aging linked to chronic stress.

Quality Specifications

Supply & Documentation

• Capacity: 100 kg per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 g, 5 g, 10 g, 50 g, 100 g in amber glass vials or as customized

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com