데아자플라빈(TND-1128)
| 제품명 | Deazaflavin |
| 다른 이름 | TND-1128 |
| CAS 번호 | 59997-14-7 |
| 분자식 | C₁₂H₉N₃O₂ |
| 분자량 | 227.22 g/mol |
| 외관 | Yellow to orange crystalline powder |
| 순도 (HPLC) | ≥ 98.0% |
| 건조 손실 | ≤ 0.5% |
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Deazaflavin (TND-1128) is a synthetic flavin analog belonging to the 5-deazaflavin family, characterized by the replacement of the nitrogen atom at position 5 of the isoalloxazine ring with a carbon atom. This structural modification fundamentally alters the redox chemistry of the molecule.
동의어: Deazaflavin, 5-Deazaflavin, TND-1128, Pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione, NSC 106042, Denitrifying flavin, Deazoflavin, 1H,2H,3H,4H-Pyrimido[4,5-b]quinoline-2,4-dione
Relationship to other deazaflavins:
| 복합체 | CAS 번호. | Position 5 | Key Difference |
|---|---|---|---|
| 5-데아자플라빈 | 26908-38-3 | Carbon (C) | C at position 5, H at N3? |
| Deazaflavin (TND-1128) | 59997-14-7 | Carbon (C) | Different substitution pattern |
| Natural flavin (riboflavin) | 83-88-5 | Nitrogen (N) | Natural cofactor |
| F420 cofactor | Various | Carbon (C) | Natural deazaflavin (archaea/mycobacteria) |
Unlike natural flavins (riboflavin, FMN, FAD), deazaflavin analogs cannot form the N5-C4a adduct intermediate that is critical for many flavin-catalyzed reactions. This property makes deazaflavins valuable mechanistic probes for studying flavoprotein function.
| 매개변수 | 사양 | 시험 방법 |
|---|---|---|
| 분석법 (HPLC) | ≥ 98.0% | HPLC-UV |
| 외관 | Yellow to orange crystalline powder | 시각적 |
| 건조 손실 | ≤ 0.5% | USP |
| Single Impurity | ≤ 0.5% | HPLC-UV |
| Total Impurities | ≤ 2.0% | HPLC-UV |
| 잔류 용매 | USP 소개 | GC |
| 매개변수 | Deazaflavin (TND-1128) | Riboflavin (B2) | FMN | FAD |
|---|---|---|---|---|
| Position 5 heteroatom | Carbon | Nitrogen | Nitrogen | Nitrogen |
| N5-C4a adduct formation | Cannot form | Can form | Can form | Can form |
| Reduction potential | More negative (~ -0.65 V) | ~ -0.30 V | ~ -0.32 V | ~ -0.32 V |
| Oxygen reactivity | Reduced | 높음 | 높음 | 높음 |
| Natural occurrence | Synthetic (analog of F420) | Natural | Natural | Natural |
| Primary application | Mechanistic probe | Supplement | Research | Research |
LyvBio 주식회사. is a supplier of high-purity Deazaflavin (TND-1128) for research and development applications.
공급 역량:
순도: ≥98.0% (HPLC)
대량 주문: 50g-200g
리드 타임: 3-5 business days (stock items)
문서: COA, MSDS, HPLC chromatogram
Source: Synthetic chemical synthesis
Standardization: ≥98.0% deazaflavin (HPLC)
Forms: Yellow to light yellow crystalline powder
응용 분야: Biochemical research, pharmaceutical analysis, enzyme mechanism studies
Q: What is the difference between deazaflavin and natural flavins?
A: Deazaflavin has a carbon atom at position 5 instead of nitrogen, which alters its redox potential and electron transfer properties, making it useful as a mechanistic probe.
Q: What is TND-1128?
A: TND-1128 is a research compound identifier used for deazaflavin in pharmacological screening and impurity profiling, particularly as a Vecabrutinib impurity reference.
Q: Is deazaflavin suitable for in vitro studies?
A: Yes, deazaflavin is soluble in DMSO and DMF, making it suitable for in vitro biochemical and enzymatic assays.
Q: What documentation is provided?
A: We provide COA, HPLC chromatogram, and NMR with every shipment. Additional documents are available upon request.
Q: Is deazaflavin suitable for long-term storage?
A: Yes, when stored in a cool, dry place, protected from light, deazaflavin is stable for at least 24 months.
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