| Product Name | Deazaflavin |
| Other Name | TND-1128 |
| CAS Number | 59997-14-7 |
| Molecular Formula | C₁₂H₉N₃O₂ |
| Molecular Weight | 227.22 g/mol |
| Appearance | Yellow to orange crystalline powder |
| Purity (HPLC) | ≥ 98.0% |
| Loss on Drying | ≤ 0.5% |
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Deazaflavin (TND-1128) is a synthetic flavin analog belonging to the 5-deazaflavin family, characterized by the replacement of the nitrogen atom at position 5 of the isoalloxazine ring with a carbon atom. This structural modification fundamentally alters the redox chemistry of the molecule.
Relationship to other deazaflavins:
| Compound | CAS No. | Position 5 | Key Difference |
|---|---|---|---|
| 5-Deazaflavin | 26908-38-3 | Carbon (C) | C at position 5, H at N3? |
| Deazaflavin (TND-1128) | 59997-14-7 | Carbon (C) | Different substitution pattern |
| Natural flavin (riboflavin) | 83-88-5 | Nitrogen (N) | Natural cofactor |
| F420 cofactor | Various | Carbon (C) | Natural deazaflavin (archaea/mycobacteria) |
Unlike natural flavins (riboflavin, FMN, FAD), deazaflavin analogs cannot form the N5-C4a adduct intermediate that is critical for many flavin-catalyzed reactions. This property makes deazaflavins valuable mechanistic probes for studying flavoprotein function.
| Parameter | Specification | Test Method |
|---|---|---|
| Assay (HPLC) | ≥ 98.0% | HPLC-UV |
| Appearance | Yellow to orange crystalline powder | Visual |
| Loss on Drying | ≤ 0.5% | USP <731> |
| Single Impurity | ≤ 0.5% | HPLC-UV |
| Total Impurities | ≤ 2.0% | HPLC-UV |
| Residual Solvents | Meet USP <467> | GC |
| Parameter | Deazaflavin (TND-1128) | Riboflavin (B2) | FMN | FAD |
|---|---|---|---|---|
| Position 5 heteroatom | Carbon | Nitrogen | Nitrogen | Nitrogen |
| N5-C4a adduct formation | Cannot form | Can form | Can form | Can form |
| Reduction potential | More negative (~ -0.65 V) | ~ -0.30 V | ~ -0.32 V | ~ -0.32 V |
| Oxygen reactivity | Reduced | High | High | High |
| Natural occurrence | Synthetic (analog of F420) | Natural | Natural | Natural |
| Primary application | Mechanistic probe | Supplement | Research | Research |
LyvBio Co., Ltd. is a supplier of high-purity Deazaflavin (TND-1128) for research and development applications.
Supply capabilities:
Purity: ≥98.0% (HPLC)
Bulk quantities: 100mg – 50g
Lead time: 3–5 days (samples), 10–15 days (bulk)
Documentation: COA, MSDS, HPLC chromatogram
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