| Nom du produit | Metformin Hydrochloride |
|---|---|
| Numéro CAS | 1115-70-4 |
| Formule moléculaire | C₄H₁₁N₅ · HCl |
| Poids moléculaire | 165.62 g/mol |
| Apparence | Poudre cristalline blanche |
| Essai (HPLC) | ≥ 98.0% |
| Perte au séchage | ≤ 0,5% |
| Résidu au feu | ≤ 0,11 TP3T |
| Métaux lourds | ≤ 10 ppm |
| Point de fusion | 223 – 226°C |
| pH (solution 1%) | 5.0 – 7.0 |
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Metformin Hydrochloride is a biguanide compound and the hydrochloride salt form of metformin. It is one of the most widely prescribed oral antidiabetic agents in the world, recognized as the first‑line pharmacological treatment for type 2 diabetes mellitus. Metformin has been used clinically for over 60 years and is included on the WHO Model List of Essential Medicines.
Metformin works primarily by reducing hepatic glucose production (gluconeogenesis), increasing peripheral insulin sensitivity, and enhancing glucose uptake in muscle and adipose tissue. It also has beneficial effects on lipid metabolism and body weight, making it a preferred choice for patients with type 2 diabetes and obesity.
In addition to its antidiabetic applications, metformin is widely studied for its potential in anti‑aging, cardiovascular health, polycystic ovary syndrome (PCOS), and cancer prevention. Its safety profile, low cost, and multifactorial benefits have made it a compound of significant research interest beyond diabetes management.
Hepatic glucose reduction: Inhibits gluconeogenesis and glycogenolysis in the liver.
Insulin sensitivity improvement: Enhances peripheral glucose uptake and utilization.
Gestion du poids: Associated with weight neutrality or modest weight loss.
Soutien au profil lipidique: Modulates triglyceride and cholesterol levels.
Source: Chemical synthesis
Normalisation: ≥98.0% metformin HCl (HPLC)
Formulaires: Poudre cristalline blanche
Applications: Pharmaceutical APIs, dietary supplements, research reagents, anti‑aging formulations
| Paramètre | Spécifications |
|---|---|
| Metformin HCl Content (HPLC) | ≥ 98.0% |
| Identification | IR / UV spectrum conforms to reference |
| pH (solution 1%) | 5.0 – 7.0 |
| Cyanoguanidine (impurity) | ≤ 0.003% |
| Perte au séchage | ≤ 0,5% |
| Résidu au feu | ≤ 0,11 TP3T |
| Métaux lourds (exprimés en Pb) | ≤ 10 ppm |
| Arsenic (As) | ≤ 1 ppm |
| Limites microbiologiques | Conforme aux normes USP/EP |
Capacité mensuelle: plus de 1 000 kg
Délai de livraison: 3 à 5 jours (échantillons), 10 à 15 jours (en vrac)
Documentation: certificat d'analyse, fiche de données de sécurité
Emballage: 1 kg, 5 kg, 10 kg, 25 kg
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