Sodium Taurodeoxycholate Hydrate

Từ đồng nghĩa: Sodium taurodeoxycholate hydrate, Taurodeoxycholic acid sodium salt hydrate, Sodium 2-[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]aminoethanesulfonate hydrate, Deoxycholyltaurine sodium salt hydrate, Tauro-3α,12α-dihydroxy-5β-cholan-24-oic acid sodium salt hydrate

In the evolving landscape of bile acid research, sodium taurodeoxycholate hydrate has become a molecule of considerable interest for formulators and scientists working on advanced drug delivery and metabolic studies. Its unique amphiphilic character and high purity make it a preferred choice for stabilizing membrane proteins in structural biology and for enhancing the oral bioavailability of poorly soluble drugs. As the pharmaceutical industry increasingly focuses on targeted therapies and personalized medicine, the demand for well-characterized bile salts like this one continues to grow.

Sodium taurodeoxycholate hydrate is the sodium salt form of taurodeoxycholic acid, a secondary bile acid conjugated with taurine. It occurs naturally in the bile of mammals, particularly in humans and other primates, where it plays a crucial role in the emulsification and absorption of dietary fats. The compound is typically produced through chemical synthesis or semi-synthesis from deoxycholic acid, followed by conjugation with taurine and subsequent salt formation. This synthetic route ensures consistent quality and supply, independent of animal-derived raw materials.

Our sodium taurodeoxycholate hydrate is manufactured under strict quality control to meet the demands of pharmaceutical and biotechnological applications. With an assay of ≥97% (HPLC), it offers reliable performance in critical processes such as protein solubilization, liposome preparation, and as a permeation enhancer in drug delivery systems. The hydrate form provides improved stability and handling characteristics compared to the anhydrous form, making it easier to incorporate into aqueous formulations.

Product Overview & Composition

Chemically, sodium taurodeoxycholate hydrate is a steroidal bile salt with a hydrophilic taurine moiety and a hydrophobic steroid nucleus. This structure confers detergent-like properties, allowing it to form micelles and solubilize lipids and hydrophobic compounds in aqueous environments. The hydrate form contains variable amounts of water (typically 3-5% w/w), which should be considered when calculating molar concentrations. The compound is highly soluble in water, forming clear, colorless solutions that are stable under recommended storage conditions.

In biological systems, taurodeoxycholate acts as a signaling molecule and a detergent, influencing lipid metabolism and membrane dynamics. Its ability to activate nuclear receptors such as FXR and TGR5 has made it a valuable tool in metabolic research. For industrial applications, the consistent purity and low heavy metal content of our product ensure reproducible results in sensitive assays and manufacturing processes.

Key Applications

• Membrane protein research: Used for solubilization and stabilization of integral membrane proteins in structural biology and biochemistry, particularly in NMR and crystallography studies.
• Drug delivery systems: Enhances permeation of poorly absorbable drugs across biological membranes; employed in oral, nasal, and transdermal formulations.
• Liposome and nanoparticle preparation: Acts as a detergent to control particle size and stability during liposome formation for targeted drug delivery.
• Cell culture and bioprocessing: Added to media to improve cell growth and protein expression, especially in CHO and HEK293 cell lines.
• Metabolic and liver research: Serves as a tool to study bile acid signaling, cholesterol homeostasis, and liver disease mechanisms.
• Analytical chemistry: Utilized as a reference standard and ion-pairing reagent in LC-MS and other analytical techniques.

Quality & Standards

Packaging & Supply

• Bao bì: 1 kg, 5 kg, and 25 kg fiber drums with double polyethylene liners; custom packaging available upon request.
• MOQ: 1 kg for standard packaging; flexible for trial orders.
• Thời gian thực hiện: 3-5 business days (stock items)
• Tài liệu hướng dẫn: COA, MSDS, TDS, and additional technical support provided with each shipment.
• Lưu trữ: Recommended storage at 2-8°C in a dry, well-ventilated area away from direct sunlight.

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