Ricobendazole / Albendazole Sulfoxide
| Tham số | Thông số kỹ thuật |
|---|---|
| Tên sản phẩm | Ricobendazole / Albendazole Sulfoxide |
| Số CAS | 54029-14-0 |
| Công thức phân tử | C12H15N3O3S |
| Trọng lượng phân tử | 281.33 g/mol |
| Hình thức | Bột tinh thể màu trắng đến trắng ngà |
| Phương pháp phân tích (HPLC) | ≥98,01 TP3T |
| Độ hòa tan | Sparingly soluble in water, soluble in DMSO and methanol |
| Gói | 25 kg fiber drum with double polyethylene liner |
Cần trợ giúp? Liên hệ với đội ngũ của chúng tôi
Từ đồng nghĩa: Albendazole Sulfoxide, Ricobendazole, Methyl (5-(propylsulfinyl)-1H-benzimidazol-2-yl)carbamate, Albendazole oxide, ABZSO
Ricobendazole, also known as albendazole sulfoxide, is the active metabolite of albendazole and a chiral benzimidazole carbamate. Its core is a benzimidazole ring bearing a propylsulfinyl group at the 5-position and a methyl carbamate at the 2-position. The sulfoxide functionality introduces a stereogenic center, and the drug is typically supplied as the racemate, though enantiomers differ in pharmacokinetic behavior. This structural motif underpins its interaction with β-tubulin, disrupting microtubule dynamics in helminths.
Industrially, ricobendazole is produced by controlled oxidation of albendazole, yielding a high-purity API that meets pharmacopeial standards. It appears as a white to off-white crystalline powder, sparingly soluble in water but freely soluble in polar aprotic solvents such as DMSO. The compound is stable under normal storage conditions but should be protected from light and moisture to prevent degradation.
As a formulated intermediate and API, ricobendazole serves veterinary and pharmaceutical manufacturers targeting gastrointestinal nematodes and tissue-dwelling parasites. Its improved aqueous solubility relative to albendazole makes it suitable for injectable and oral formulations, while its defined metabolite profile supports use in pharmacokinetic and bioequivalence studies.
The molecule combines a benzimidazole nucleus with a sulfinyl side chain, which enhances polarity and modifies tissue distribution. The sulfoxide group is susceptible to reversible reduction, but under recommended storage conditions the compound remains chemically stable. Its logP is moderate, supporting membrane permeability while allowing for formulation in aqueous vehicles.
| Test Item | Thông số kỹ thuật |
|---|---|
| Xác định | IR and HPLC retention time conform to reference standard |
| Mất mát khi sấy khô | ≤0.5% |
| Hàm lượng tro sau khi đốt | ≤0.1% |
| Kim loại nặng | ≤20 ppm |
| Các chất liên quan | Any individual impurity ≤0.5%; total impurities ≤1.0% |
| Giới hạn vi sinh vật | Total aerobic count ≤1000 CFU/g; yeast and mold ≤100 CFU/g; absence of E. coli and Salmonella |
Our standard MOQ is 1 kg for trial orders, with competitive pricing for bulk quantities.
For stock items, delivery is 3-5 business days from order confirmation.
Yes, we provide a COA for each batch and can supply samples for quality evaluation. Sample dispatch typically takes 1-2 days.
send us your specification for a quotation.
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