Ricobendazole / Albendazole Sulfoxide

동의어: Albendazole Sulfoxide, Ricobendazole, Methyl (5-(propylsulfinyl)-1H-benzimidazol-2-yl)carbamate, Albendazole oxide, ABZSO

Ricobendazole, also known as albendazole sulfoxide, is the active metabolite of albendazole and a chiral benzimidazole carbamate. Its core is a benzimidazole ring bearing a propylsulfinyl group at the 5-position and a methyl carbamate at the 2-position. The sulfoxide functionality introduces a stereogenic center, and the drug is typically supplied as the racemate, though enantiomers differ in pharmacokinetic behavior. This structural motif underpins its interaction with β-tubulin, disrupting microtubule dynamics in helminths.

Industrially, ricobendazole is produced by controlled oxidation of albendazole, yielding a high-purity API that meets pharmacopeial standards. It appears as a white to off-white crystalline powder, sparingly soluble in water but freely soluble in polar aprotic solvents such as DMSO. The compound is stable under normal storage conditions but should be protected from light and moisture to prevent degradation.

As a formulated intermediate and API, ricobendazole serves veterinary and pharmaceutical manufacturers targeting gastrointestinal nematodes and tissue-dwelling parasites. Its improved aqueous solubility relative to albendazole makes it suitable for injectable and oral formulations, while its defined metabolite profile supports use in pharmacokinetic and bioequivalence studies.

Chemical Structure & Properties

The molecule combines a benzimidazole nucleus with a sulfinyl side chain, which enhances polarity and modifies tissue distribution. The sulfoxide group is susceptible to reversible reduction, but under recommended storage conditions the compound remains chemically stable. Its logP is moderate, supporting membrane permeability while allowing for formulation in aqueous vehicles.

작용 기전

• β-Tubulin binding: Binds to helminth β-tubulin, inhibiting microtubule polymerization and disrupting cellular transport.
• Energy metabolism interference: Impairs glucose uptake and ATP production, leading to parasite immobilization and death.
• Selective toxicity: Higher affinity for parasite tubulin over mammalian tubulin reduces host toxicity.
• Ovicidal and larvicidal effects: Prevents egg hatching and larval development, reducing environmental contamination.

Quality Specifications (QC Tests)

Supply & Documentation

• Capacity: 5 metric tons per month
• 리드 타임: 3-5 business days (stock items)
• 문서: COA, MSDS, TDS available upon request
• 포장: 25 kg fiber drum with double polyethylene liner, or customized packaging for small quantities

자주 묻는 질문

What is the minimum order quantity?

Our standard MOQ is 1 kg for trial orders, with competitive pricing for bulk quantities.

How long does delivery take?

For stock items, delivery is 3-5 business days from order confirmation.

Can you provide a COA and samples?

Yes, we provide a COA for each batch and can supply samples for quality evaluation. Sample dispatch typically takes 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.