Pantoprazole
| Tham số | Thông số kỹ thuật |
|---|---|
| Tên sản phẩm | Pantoprazole |
| Số CAS | 102625-70-7 |
| Công thức phân tử | C16H15F2N3O4S |
| Trọng lượng phân tử | 383.37 g/mol |
| Hình thức | Bột tinh thể màu trắng đến trắng ngà |
| Phương pháp phân tích (HPLC) | ≥ 99.0% (anhydrous basis) |
| Độ hòa tan | Slightly soluble in water, freely soluble in methanol, practically insoluble in hexane |
| Gói | 25 kg fiber drum with double polyethylene liner |
Cần trợ giúp? Liên hệ với đội ngũ của chúng tôi
Từ đồng nghĩa: Pantoprazole, 5-(Difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridinyl)methylsulfinyl]-1H-benzimidazole, SKF-96022, BY-1023, Pantoloc, Protonix
Pantoprazole is a substituted benzimidazole derivative that acts as a proton pump inhibitor (PPI). Its chemical structure features a difluoromethoxy-substituted benzimidazole ring linked via a methylsulfinyl bridge to a dimethoxypyridine moiety. This configuration allows the molecule to accumulate in the acidic environment of gastric parietal cell canaliculi, where it undergoes acid-catalyzed activation to a reactive sulfenamide that covalently binds to the H+/K+-ATPase enzyme, thereby suppressing gastric acid secretion.
Discovered in the early 1990s, pantoprazole is marketed under brand names such as Protonix and Pantoloc. It is indicated for the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, and pathological hypersecretory conditions including Zollinger-Ellison syndrome. The compound is also a key API for generic drug manufacturers, and its sodium salt form is commonly used in injectable formulations for acute settings.
In pharmaceutical development, pantoprazole serves as a reference standard for analytical method validation and as a starting material for salt formation and formulation studies. Its selective mechanism and favorable safety profile have made it a staple in both clinical practice and bulk pharmaceutical supply chains.
Pantoprazole belongs to the class of 2-pyridylmethylsulfinyl benzimidazoles. The molecule contains a difluoromethoxy group on the benzimidazole ring, which enhances its lipophilicity and influences its pKa (approximately 3.8 for the pyridine nitrogen). The sulfinyl group is chiral, but pantoprazole is administered as a racemic mixture. It appears as a white to off-white crystalline powder, with a melting point range of 139–141°C (decomposition). The compound is stable under normal storage conditions but degrades in strong acidic media, a property that underlies its targeted activation in vivo.
| Test Item | Thông số kỹ thuật |
|---|---|
| Identification (IR, HPLC) | Complies with reference standard |
| Mất mát khi sấy khô | ≤ 0,5% |
| Hàm lượng tro sau khi đốt | ≤ 0,1% |
| Kim loại nặng | ≤ 20 ppm |
| Các chất liên quan | Total impurities ≤ 0.5%; each unspecified ≤ 0.1% |
| Giới hạn vi sinh vật | Total aerobic count ≤ 1000 cfu/g; yeast and mold ≤ 100 cfu/g; E. coli absent |
Our standard MOQ is 1 kg for stock items. For larger quantities, please contact our sales team to discuss volume pricing and availability.
For stock items, delivery is 3-5 business days from order confirmation. We ship globally via air or sea freight, depending on your location and preference.
Yes, we provide a COA for every batch and can supply samples for quality evaluation. Samples are typically dispatched within 1-2 days after request, and shipping costs may apply.
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