Pantoprazole

同義語： Pantoprazole, 5-(Difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridinyl)methylsulfinyl]-1H-benzimidazole, SKF-96022, BY-1023, Pantoloc, Protonix

Pantoprazole is a substituted benzimidazole derivative that acts as a proton pump inhibitor (PPI). Its chemical structure features a difluoromethoxy-substituted benzimidazole ring linked via a methylsulfinyl bridge to a dimethoxypyridine moiety. This configuration allows the molecule to accumulate in the acidic environment of gastric parietal cell canaliculi, where it undergoes acid-catalyzed activation to a reactive sulfenamide that covalently binds to the H+/K+-ATPase enzyme, thereby suppressing gastric acid secretion.

Discovered in the early 1990s, pantoprazole is marketed under brand names such as Protonix and Pantoloc. It is indicated for the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, and pathological hypersecretory conditions including Zollinger-Ellison syndrome. The compound is also a key API for generic drug manufacturers, and its sodium salt form is commonly used in injectable formulations for acute settings.

In pharmaceutical development, pantoprazole serves as a reference standard for analytical method validation and as a starting material for salt formation and formulation studies. Its selective mechanism and favorable safety profile have made it a staple in both clinical practice and bulk pharmaceutical supply chains.

化学構造と性質

Pantoprazole belongs to the class of 2-pyridylmethylsulfinyl benzimidazoles. The molecule contains a difluoromethoxy group on the benzimidazole ring, which enhances its lipophilicity and influences its pKa (approximately 3.8 for the pyridine nitrogen). The sulfinyl group is chiral, but pantoprazole is administered as a racemic mixture. It appears as a white to off-white crystalline powder, with a melting point range of 139–141°C (decomposition). The compound is stable under normal storage conditions but degrades in strong acidic media, a property that underlies its targeted activation in vivo.

作用機序

• Proton pump inhibition: Pantoprazole is a prodrug that requires acidic activation. In the parietal cell canaliculus, it is converted to a tetracyclic sulfenamide, which then forms disulfide bonds with cysteine residues on the H+/K+-ATPase, irreversibly blocking acid secretion.
• Selectivity: Due to its pKa, pantoprazole accumulates preferentially in acidic compartments, minimizing systemic effects on other ATPases.
• Reversible binding: Unlike some PPIs, pantoprazole shows reversible binding to cysteine 822, but irreversible inhibition of the pump occurs through cysteine 813 and 892.
• Onset and duration: Acid suppression begins within 1 hour of oral administration, with maximal effect after 2–4 hours. The effect lasts up to 24 hours due to the irreversible nature of the inhibition.

Quality Specifications (QC Tests)

供給および書類

• 容量: Up to 5 metric tons per month
• リードタイム: 3～5営業日（在庫品）
• ドキュメント: COA, MSDS, TDS, and additional regulatory support available upon request
• パッケージ: 25 kg fiber drum with double polyethylene liner, or customized packaging for small quantities

よくある質問

What is the minimum order quantity (MOQ) for Pantoprazole?

Our standard MOQ is 1 kg for stock items. For larger quantities, please contact our sales team to discuss volume pricing and availability.

What is the typical delivery time?

For stock items, delivery is 3-5 business days from order confirmation. We ship globally via air or sea freight, depending on your location and preference.

Can you provide a COA and sample for evaluation?

Yes, we provide a COA for every batch and can supply samples for quality evaluation. Samples are typically dispatched within 1-2 days after request, and shipping costs may apply.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.