| Tên sản phẩm | NMNH (Reduced Nicotinamide Mononucleotide) |
| Các tên gọi khác | NMNH; Reduced NMN; Dihydronicotinamide mononucleotide |
| Số CAS | 108347-85-9 |
| Công thức phân tử | C₁₁H₁₇N₂O₈P |
| Trọng lượng phân tử | 336.23 g/mol |
| Hình thức | Yellow to light yellow crystalline powder |
| Phương pháp phân tích (HPLC) | ≥ 98.0% (high purity) |
| Purity (NAD⁺/NMN related) | ≤ 5.0% oxidized forms |
Cần trợ giúp? Liên hệ với đội ngũ của chúng tôi
NMNH (Reduced Nicotinamide Mononucleotide) is the reduced form of nicotinamide mononucleotide (NMN). While NMN contains a nicotinamide ring in its oxidized state, NMNH features a dihydropyridine ring, making it chemically similar to NADH but at the mononucleotide level.
NMNH represents an emerging area of NAD⁺ precursor research. Unlike NMN (which must be converted to NAD⁺ via NMNAT enzymes), NMNH is believed to be more readily converted to NADH and may elevate cellular NAD⁺ levels through distinct metabolic pathways. Early research suggests potentially higher bioavailability and different tissue distribution compared to NMN.
C₁₁H₁₈N₂NaO₈P
| Hợp chất | Số CAS. | Trọng lượng phân tử | Oxidation State | Ring Structure |
|---|---|---|---|---|
| NMN (β-Nicotinamide Mononucleotide) | 1094-61-7 | 334.22 g/mol | Oxidized | Pyridine ring |
| NMNH (Reduced NMN) | 108347-85-9 | 336.23 g/mol | Giảm | Dihydropyridine ring |
| NAD⁺ | 53-84-9 | 663.43 g/mol | Oxidized | Pyridine ring |
| NADH | 606-68-8 | 665.44 g/mol | Giảm | Dihydropyridine ring |
| Ứng dụng | Mô tả | Người dùng cuối |
|---|---|---|
| NAD⁺ metabolism research | Studying alternative NAD⁺ biosynthesis pathways | Nghiên cứu học thuật, các trường đại học |
| Aging & longevity research | Comparative studies with NMN, NR, NADH | Aging research institutes |
| Metabolic disease models | In vitro and animal studies of energy metabolism | Pharmaceutical R&D, CROs |
| Enzymology studies | Substrate specificity of NMNAT, NRK, CD38 enzymes | Biochemistry research |
| Research Focus | NMNH vs. NMN vs. NR vs. NADH |
|---|---|
| Bioavailability | Which precursor elevates NAD⁺/NADH most efficiently? |
| Tissue distribution | Does NMNH target different organs (liver, brain, muscle)? |
| Kinetics | How quickly does each precursor elevate NAD⁺/NADH? |
| Stability | Comparative stability under physiological conditions |
| Toxicity profile | Safety assessment in animal models |
| Ứng dụng | Mô tả |
|---|---|
| Stabilization technology | Developing stabilized NMNH for potential oral delivery |
| Liposomal encapsulation | Enhancing stability and bioavailability |
| Analytical method development | HPLC, LC-MS methods for NMNH quantification |
Công ty TNHH LyvBio. is a GMP-certified supplier of high-purity NMNH (Reduced NMN) for research and development applications.
Năng lực cung ứng:
Phương pháp định lượng (HPLC): ≥95.0% (standard), ≥98.0% (high purity)
Hình thức: Yellow to light yellow crystalline powder
Biểu mẫu: Lyophilized crystalline powder
Công suất hàng tháng: 500g – 1kg
Số lượng lớn: 100mg – 500g
Thời gian giao hàng: 3–5 ngày (mẫu), 10–15 ngày (số lượng lớn)
Tài liệu: Giấy chứng nhận xuất xứ (COA), Bảng dữ liệu an toàn hóa chất (MSDS), Bảng dữ liệu kỹ thuật (TDS), Đồ thị sắc ký HPLC, Dữ liệu ổn định, Phổ cộng hưởng từ hạt nhân (NMR) (theo yêu cầu)
Đảm bảo chất lượng:
HPLC purity with UV detection (260 nm for oxidized forms, 340 nm for reduced forms)
Controlled storage and handling (-20°C freezer, inert atmosphere)
Stability-tested batches
📧 Liên hệ: info@lyvbio.com
| Tham số | Bảo tàng Lịch sử Tự nhiên Quốc gia | NMN | NR Chloride | NADH |
|---|---|---|---|---|
| Số CAS. | 108347-85-9 | 1094-61-7 | 23111-00-4 | 606-68-8 |
| Trọng lượng phân tử | 336.23 | 334.22 | 290.70 | 665.44 |
| Oxidation state | Giảm | Oxidized | Oxidized (precursor) | Giảm |
| Hình thức | Yellow crystalline | White powder | White powder | White powder |
| Primary role | NADH precursor | NAD⁺ precursor | NAD⁺ precursor | Electron donor (ATP) |
| Stability | Very poor (requires -20°C, inert) | Poor | Moderate | Very poor |
| Human clinical data | None (research only) | Limited | Extensive (20+ trials) | Limited |
| Regulatory status (USA) | Not GRAS (research only) | Not lawful as supplement* | GRAS | Not GRAS |
| Typical research dose | Not applicable (preclinical) | 250–500 mg | 250–500 mg | 5–50 mg |
| Primary market | R&D / preclinical | Research (limited supplement) | Dietary supplements | Dietary supplements |
Q: What is the difference between NMNH and NMN?
A: NMNH is the reduced form of NMN (dihydropyridine ring vs. pyridine ring). NMN is oxidized; NMNH is reduced. This structural difference gives NMNH distinct chemical properties (yellow color, different UV absorption, greater instability).
Q: Is NMNH a dietary supplement?
A: Không. NMNH is a research compound. It is not GRAS, not approved as a dietary supplement in any major market, and has no human safety or efficacy data. LyvBio supplies NMNH for research and development purposes only.
Q: Why is NMNH yellow while NMN is white?
A: The yellow color is characteristic of the reduced dihydropyridine ring. NADH (reduced) is also pale yellow; NAD⁺ (oxidized) is white. This color difference is a quick visual indicator of oxidation state.
Q: Is NMNH more effective than NMN?
A: Unknown. Current research is limited to in vitro and early animal studies. No human data exist. NMNH is an emerging research area, not a proven NAD⁺ booster.
Q: How should NMNH be stored?
A: -20°C freezer, sealed, desiccated, under inert atmosphere (argon/nitrogen), protected from light. Failure to store properly results in rapid oxidation to NMN and other degradation products.
Q: What is the recommended dosage for research?
A: For in vitro studies: 10–100 µM. For animal studies: dosage varies by model. No human dosage exists. LyvBio does not provide dosing recommendations; researchers must determine appropriate concentrations.
Hỏi: Số lượng đặt hàng tối thiểu (MOQ) của quý công ty là bao nhiêu?
A: Research samples: 100mg–1g. Bulk research: 5g–100g. Lead time: 3–5 days (samples); 10–15 days (bulk). All NMNH shipments are temperature-controlled (dry ice or gel packs) with inert atmosphere packaging.
📧 Email: info@lyvbio.com
🌐 Trang web: https://www.lyvbio.com
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