Evodiamin
|
Product name |
Evodiamin |
|
CAS No. |
518-17-2 |
|
Molecular formula |
C19H17N3O |
|
Molecular weight |
303.36 |
|
Độ tinh khiết |
98.0% |
|
Hình thức |
Light yellow crystalline powder |
|
Packing |
1kg/ pack |
|
Ứng dụng |
Pharmaceutical raw material |
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Evodiamine is a bioactive alkaloid extracted from the dried, unripe fruit of Evodia rutaecarpa (also known as Tetradium ruticarpum), a plant used in Traditional Chinese Medicine for centuries. It is the primary active compound responsible for the thermogenic and metabolic effects of the herb.
Evodiamine has become a popular ingredient in weight management and thermogenic formulas due to its ability to increase energy expenditure, reduce appetite, and modulate fat metabolism. It is often positioned as a “non-stimulant thermogenic” alternative to caffeine-based fat burners.
|
Other name |
EVODIAMINE10% PLANTEXTRACT;EVODIAMINE98%; EVODIAMINE20%PLANTEXTRACT; EVODIAMINE5%PLANTEXTRACT; Evodiaminestd ; EVODIAMINE; 8,13,13b,14-Tetrahydro-14-mChemicalbookethylindolo[2’3′-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one; Indol(2′,3′:3,4)pyrido(2,1-b)quinazolin-5(7H)-one,8,13,13b,14-tetrahydro-14-methyl-,(S)- |
| Tác dụng | Cơ chế |
|---|---|
| Thermogenesis | Activates TRPV1 → increases intracellular calcium → upregulates uncoupling protein 1 (UCP1) in brown adipose tissue |
| Energy expenditure | Increases body temperature and metabolic rate |
| Appetite suppression | Reduces ghrelin (hunger hormone) and food intake (animal studies) |
| Fat oxidation | Enhances lipolysis and fatty acid utilization |
| Ứng dụng | Liều lượng thông thường | Các luận điểm chính |
|---|---|---|
| Thermogenic fat burner | 50–150 mg/day | Increases metabolic rate, calorie burning |
| Weight management formula | 50–100 mg/day | Supports healthy weight loss |
| Non-stimulant fat burner | 50–150 mg/day | Thermogenesis without jitters |
| Ứng dụng | Liều lượng thông thường | Cơ chế |
|---|---|---|
| Glucose metabolism support | 50–100 mg/day | AMPK activation, insulin sensitivity (preclinical) |
| Lipid profile support | 50–100 mg/day | May reduce triglycerides, LDL (preclinical) |
| Ứng dụng | Liều lượng thông thường | Timing |
|---|---|---|
| Pre-cardio thermogenic | 50–100 mg | 30–45 min before cardio |
| Cutting cycle support | 50–150 mg/day | Daily during fat loss phase |
Evodia rutaecarpa (Juss.)Benth
Công ty TNHH LyvBio. is a GMP-certified supplier of top purity Evodiamine for the nutraceutical, weight management, and sports nutrition industries.
Năng lực cung ứng:
Độ tinh khiết: ≥98.0% (standard), ≥99.0% (pharmaceutical grade)
Nguồn: Evodia rutaecarpa fruit (standardized extract)
Công suất hàng tháng: Hơn 500 kg
Số lượng lớn: 100 g – 5.000 kg
Thời gian thực hiện: 3-5 business days (stock items)
Tài liệu: COA, MSDS, HPLC chromatogram, stability data, allergen statement
| Tham số | Standard Grade | Phương pháp thử nghiệm |
|---|---|---|
| Phương pháp phân tích (HPLC) | ≥ 98,01 TP3T | HPLC-UV |
| Hình thức | Bột màu trắng đến trắng ngà | Hình ảnh |
| Xác định | Thời gian lưu HPLC, IR | HPLC/IR |
| Điểm nóng chảy | 263–266°C | USP |
| Mất mát khi sấy khô | ≤ 0,5% | USP |
| Hàm lượng tro sau khi đốt | ≤ 0,1% | USP |
| Kim loại nặng | ≤ 10 ppm | ICP-MS |
| Các chất liên quan | Single ≤ 0.5%; Total ≤ 2.0% | HPLC-UV |
| Chất dung môi còn lại | Giới thiệu tiêu chuẩn USP | GC |
| Kích thước hạt | 95% through 80 mesh | Sieve Analysis |
Q: Is Evodiamine a stimulant?
A: No. Evodiamine is non-stimulant. It works through TRPV1 activation (calcium signaling), not adrenergic pathways. It does not cause jitters, anxiety, or sleep disruption.
Q: Does Evodiamine cause a burning sensation like capsaicin?
A: No. Despite both activating TRPV1, evodiamine produces thermogenesis (warmth) without the burning/pain sensation of capsaicin. This makes it much more suitable for oral supplements.
Q: How does Evodiamine promote weight loss?
A: Multiple mechanisms: (1) Increases thermogenesis (UCP1 upregulation), (2) Enhances fat oxidation, (3) Reduces appetite (ghrelin suppression – animal data), (4) Inhibits fat cell formation (adipogenesis).
Q: Is Evodiamine safe for long-term use?
A: Human long-term safety data are limited. Typical usage cycles are 8–12 weeks followed by a break. At recommended doses (50–150 mg/day), it is generally well-tolerated.
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