Calcium gluconate

Synonyms: Calcium D-gluconate, D-Gluconic acid calcium salt, Gluconic acid calcium salt, Calcium gluconate USP, Calcium gluconate EP

Calcium gluconate has quietly become one of the most versatile mineral salts in the pharmaceutical and nutraceutical toolbox. Demand has been steady across injectable formulations, oral calcium supplements, and food fortification, driven by an aging population focused on bone health and by clinical protocols that rely on a fast, well-tolerated source of elemental calcium. For buyers sourcing raw materials, it is a workhorse ingredient: chemically stable, highly water-soluble, and backed by decades of safety data.

The compound is the calcium salt of gluconic acid, formed when calcium carbonate reacts with gluconic acid. The result is a white, crystalline powder that dissolves readily in water — a property that sets it apart from calcium carbonate and calcium phosphate, which can be gritty and poorly soluble at neutral pH. This high solubility makes calcium gluconate particularly valuable in liquid dosage forms, injectables, and clear beverages where mouthfeel and bioavailability matter.

Commercial grades are typically standardized to 99.0–101.0% on the dried basis, meeting USP, EP, or BP monographs. Manufacturers offer both pharmaceutical-grade material with full regulatory documentation and food-grade material for fortification. Whether you are formulating a sterile injection, a chewable tablet, or a fortified juice, calcium gluconate delivers a reliable, bioavailable calcium load without the chalky texture or gastrointestinal discomfort often associated with other calcium sources.

Product Overview & Composition

Calcium gluconate is a coordination compound in which one calcium ion is bound to two gluconate anions. The gluconate moiety is the oxidized form of glucose, and its multiple hydroxyl groups confer exceptional water solubility. This structure allows the calcium to dissociate rapidly in aqueous solution, making it immediately available for absorption or for intravenous administration.

The molecular formula is C12H22CaO14, with a molecular weight of 430.37 g/mol. In its solid state, the salt is stable under normal storage conditions; it does not readily absorb moisture, and it resists degradation at room temperature. This stability simplifies handling and extends shelf life, an important consideration for formulators and procurement teams alike.

Key Applications

• Pharmaceutical injectables: Used as a calcium replenisher in intravenous solutions for hypocalcemia, hyperkalemia, and magnesium toxicity. Its high solubility allows rapid preparation of sterile injections.
• Oral calcium supplements: A preferred source in tablets, capsules, and effervescent granules because it is gentle on the stomach and well absorbed, especially in patients with low gastric acid.
• Food and beverage fortification: Added to juices, dairy alternatives, and functional drinks to boost calcium content without sedimentation or off-flavors.
• Cardioplegic and dialysis solutions: Included in cardioplegia formulations and hemodialysis fluids to maintain calcium balance during procedures.
• Veterinary medicine: Administered to livestock and companion animals for calcium supplementation, particularly in post-parturient hypocalcemia (milk fever) in cattle.
• Cosmetics and personal care: Used in some oral care products and skin formulations as a mild calcium source and pH buffer.

Quality & Standards

Packaging & Supply

• Bao bì: 25 kg net paper bags with inner polyethylene liner, or 500 kg bulk bags. Custom packaging available upon request.
• MOQ: 500 kg for standard grades; 1,000 kg for custom particle size or documentation requirements.
• Thời gian thực hiện: 3-5 business days (stock items)
• Tài liệu hướng dẫn: COA, MSDS, TDS, and regulatory support (USP/EP/BP) provided with every shipment. Additional documentation for dietary supplement or pharmaceutical use available on request.

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