Topiramate

Синонимы

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate, Topamax, Epitomax, Topamac, TopiLEPTIN, Topiramic acid, RWJ-17021, McN-4853

Topiramate is a sulfamate-substituted monosaccharide that functions as a broad-spectrum antiepileptic agent. It is structurally distinct from other anticonvulsants, featuring a sulfamate group attached to a fructopyranose derivative. This unique structure contributes to its multifaceted mechanism of action, which includes modulation of voltage-gated sodium channels, enhancement of GABA-A receptor activity, and inhibition of carbonic anhydrase isozymes. These actions collectively stabilize neuronal membranes and reduce excitability, making it effective in managing partial-onset and generalized seizures.

Beyond its established role in epilepsy, topiramate is widely utilized in the prophylaxis of migraine headaches and has demonstrated efficacy in weight management when combined with phentermine. Its neurostabilizing properties have also been explored in psychiatric conditions such as bipolar disorder and post-traumatic stress disorder. The compound is well-absorbed orally, exhibits linear pharmacokinetics, and has a favorable safety profile, though dose titration is recommended to minimize adverse effects like paresthesia and cognitive slowing.

Функция

• Antiepileptic Activity: Blocks voltage-dependent sodium channels and potentiates GABAergic neurotransmission, thereby suppressing abnormal neuronal firing and preventing seizure propagation.
• Migraine Prophylaxis: Reduces cortical spreading depression and modulates trigeminal nociceptive pathways, leading to a significant decrease in migraine frequency and severity.
• Weight Management: Inhibits carbonic anhydrase and modulates AMPA/kainate receptors, which may contribute to reduced caloric intake and increased energy expenditure, supporting its use in obesity treatment.

Источник и чистота

• Источник: Synthetic, produced via chemical synthesis from D-fructose derivatives.
• Стандартизация: Assay by HPLC, typically 98.0% to 101.0% on anhydrous basis.
• Формы: Available as white crystalline powder; also supplied as tablets or capsules for pharmaceutical formulations.
• Приложения: Used as an active pharmaceutical ingredient (API) in the manufacture of anticonvulsant and migraine-preventive medications.

Документация и поставки

• Документация: сертификат соответствия (COA), паспорт безопасности материала (MSDS), техническое описание продукта (TDS)
• Срок выполнения заказа: 7-14 days after order confirmation.
• Упаковка: Supplied in sealed, light-resistant containers (e.g., 1 kg, 5 kg, 25 kg) with desiccant; custom packaging available upon request.

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