Sodium Taurochenodeoxycholate

Sodium Taurochenodeoxycholate

Название продукта Sodium Taurochenodeoxycholate
Номер CAS 6009-98-9
Молекулярная формула C26H44NNaO6S
Молекулярная масса 521.68 g/mol
Внешний вид Кристаллический порошок от белого до небелого цвета
Анализ (ВЭЖХ) ≥98.0%
Потери при сушке ≤5.0%
Тяжелые металлы ≤10 ppm
Растворимость Soluble in water, ethanol; practically insoluble in non-polar solvents
Упаковка 1 kg, 5 kg, 25 kg fiber drums with inner polyethylene bags

Sodium Taurochenodeoxycholate Structure

Синонимы: TCDCA sodium salt, Sodium taurochenodeoxycholate, Taurochenodeoxycholic acid sodium salt, 2-[(3α,5β,7α)-3,7-Dihydroxy-24-oxocholan-24-yl]aminoethanesulfonic acid sodium salt, Chenodeoxycholyltaurine sodium salt

Sodium Taurochenodeoxycholate (TCDCA) is the sodium salt form of taurochenodeoxycholic acid, a primary bile acid conjugated with taurine. It occurs naturally in the bile of mammals, including humans, and plays a critical role in lipid digestion and absorption. As a commercial product, it is typically produced through chemical synthesis or semi-synthesis from chenodeoxycholic acid, ensuring high purity and consistent quality for industrial and research applications.

In the pharmaceutical and biotechnology sectors, TCDCA is valued for its ability to modulate bile acid receptors such as FXR and TGR5, making it a subject of interest in metabolic and liver-related research. It also serves as a key component in cell culture media, particularly for hepatocyte studies, and as a reference standard in analytical chemistry. Its amphiphilic nature allows it to act as a detergent, facilitating the solubilization of membrane proteins and lipids in various biochemical assays.

Основные особенности продукта

  • Высокая степень очистки: ≥98% by HPLC, ensuring reliable performance in sensitive applications.
  • Поддержка в области нормативно-правового регулирования: Manufactured under cGMP conditions; DMF and CEP available upon request.
  • Consistent Supply: Annual production capacity exceeding 10 metric tons, with scalable synthesis.
  • Quality Assurance: Each batch is tested for assay, residual solvents, heavy metals, and microbial limits.
  • Индивидуальная упаковка: Available in various pack sizes to meet R&D and production needs.
  • Technical Support: Dedicated team to assist with formulation and regulatory inquiries.

Приложения

  • Pharmaceutical Research: Used as a tool compound in studies of bile acid signaling, lipid metabolism, and liver diseases.
  • Cell Culture: Supplement for hepatocyte maintenance and differentiation media.
  • Analytical Standards: Reference material for HPLC, LC-MS, and other analytical methods.
  • Biochemical Assays: Employed as a detergent for membrane protein solubilization.
  • Nutraceuticals: Investigated for potential health benefits related to bile acid modulation.

Технические характеристики

Параметр Технические характеристики
Анализ (ВЭЖХ) ≥98.0%
Внешний вид White to off-white powder
Идентификация IR, NMR conforms to structure
Потери при сушке ≤5.0%
Тяжелые металлы ≤10 ppm
Остаточные растворители Meets ICH Q3C limits
Microbial Limits Total aerobic count ≤1000 CFU/g; Yeast & Mold ≤100 CFU/g

Заказы и поставки

  • Упаковка: 1 kg, 5 kg, 25 kg fiber drums with double polyethylene liners.
  • Минимальный объем заказа: 1 kg for standard packs; custom quantities available.
  • Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
  • Документация: COA, MSDS, TDS, and regulatory support provided with each shipment.
  • Storage: Store in a cool, dry place, away from direct sunlight.

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