Семаглутид

Synonyms: Semaglutide, 910463-68-2, GLP-1 receptor agonist, GLP-1 analog, Semaglutide (USAN), Ozempic, Wegovy

Semaglutide is a synthetic analog of the human glucagon-like peptide-1 (GLP-1), a key incretin hormone that regulates glucose metabolism and appetite. It is a 31-amino acid peptide with a fatty acid side chain that enables extended half-life and once-weekly dosing. Developed for the treatment of type 2 diabetes and obesity, semaglutide has become a benchmark in the growing class of GLP-1 receptor agonists.

The molecule was engineered by substituting specific amino acids and attaching a C18 fatty diacid via a hydrophilic spacer, which promotes strong binding to albumin and slows renal clearance. This structural design allows for maintaining therapeutic concentrations over a week, a significant improvement over earlier GLP-1 analogs that required daily injections. Semaglutide is also being investigated for cardiovascular benefits and non-alcoholic steatohepatitis (NASH), reflecting its expanding clinical relevance.

As a research-grade peptide, semaglutide is supplied for laboratory use, including preclinical studies, analytical method development, and formulation research. It is typically offered as a lyophilized powder with a purity of at least 98% by HPLC, ensuring reliable performance in a range of experimental settings.

Функция

• GLP-1 receptor activation: Stimulates insulin secretion in a glucose-dependent manner.
• Appetite regulation: Reduces food intake and promotes satiety.
• Beta-cell protection: Supports pancreatic beta-cell function.
• Cardiovascular benefits: May lower risk of major adverse cardiovascular events.

Источник и стандартизация

• Источник: Synthetic peptide, manufactured via solid-phase peptide synthesis.
• Извлечение: Not applicable; produced by chemical synthesis.
• Стандартизация: Purity ≥98% by HPLC; identity confirmed by mass spectrometry.
• Формы: Lyophilized powder (as acetate or TFA salt).
• Приложения: Research use only; not for human or veterinary use.

Технические характеристики

Документация и поставки

• Ежемесячная производственная мощность: 5 kg
• Срок выполнения заказа: 5–10 working days after order confirmation
• Документация: сертификат соответствия (COA), паспорт безопасности материала (MSDS), техническое описание продукта (TDS)
• Упаковка: Double polyethylene bags inside aluminum foil bag; custom packaging available

Запрос Цитировать

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• LyvBio Co., Ltd. — Электронная почта: info@lyvbio.com