Palmitoyl Tripeptide-8

Синонимы: Palmitoyl Tripeptide-8, Palmitoyl Tripeptide-8 (Cosmetic Peptide), N-Palmitoyl Tripeptide-8, Pal-Tripeptide-8, Tripeptide-8 Palmitate

In the fast-evolving world of cosmetic actives, Palmitoyl Tripeptide-8 has carved out a distinct niche as a neuropeptide-inspired ingredient that addresses skin reactivity and discomfort. Formulators increasingly turn to it when developing products for sensitive or reactive skin, where traditional anti-aging actives may be too aggressive. Its ability to modulate the skin’s response to stress without irritation has made it a staple in premium dermal care lines, from soothing serums to post-procedure creams.

This synthetic tripeptide is a derivative of the natural neuropeptide substance P, with a palmitoyl chain attached to enhance skin penetration and stability. It works by interacting with the neurokinin-1 receptor, temporarily reducing the release of pro-inflammatory signals that lead to redness, itching, and stinging. Unlike many peptides that focus solely on collagen stimulation, Palmitoyl Tripeptide-8 targets the sensory side of skin health, offering a calming effect that complements barrier-repair strategies.

We supply Palmitoyl Tripeptide-8 with a minimum purity of 98% as confirmed by HPLC, ensuring consistent performance in finished formulations. Our material is synthesized under strict quality control, with each batch tested for residual solvents, heavy metals, and microbial content. Whether you are developing a product for rosacea-prone skin or a post-laser recovery cream, this peptide delivers reliable soothing benefits without compromising on efficacy.

Product Overview & Composition

Palmitoyl Tripeptide-8 is composed of three amino acids—arginine, proline, and lysine—linked to a palmitic acid chain. This lipophilic modification allows the molecule to penetrate the stratum corneum more effectively than unmodified peptides. The peptide backbone mimics the N-terminal sequence of substance P, enabling it to act as a competitive antagonist at the neurokinin-1 receptor. This mechanism reduces the transmission of itch and pain signals, which are often amplified in sensitive skin conditions.

In formulation, it is typically used at concentrations ranging from 0.001% to 0.01%, depending on the desired effect. It is compatible with a wide range of cosmetic ingredients, including hyaluronic acid, niacinamide, and botanical extracts. The powder form is easy to incorporate into water-based or emulsion systems, and it remains stable over a broad pH range (4.0–8.0). Its low molecular weight and palmitoyl group ensure good bioavailability in the skin’s upper layers.

Key Applications

• Sensitive skin care: Reduces redness, stinging, and itching associated with reactive skin conditions.
• Anti-aging formulations: Helps prevent the formation of fine lines caused by repetitive facial expressions when combined with other peptides.
• Post-procedure recovery: Soothes skin after chemical peels, laser treatments, or microneedling.
• Scalp care: Alleviates discomfort in scalp treatments targeting sensitivity or irritation.
• Eye contour products: Minimizes puffiness and dark circles linked to vascular reactivity.

Quality & Standards

Packaging & Supply

• Packaging: 1 kg, 5 kg, 10 kg in double PE bags inside fiber drums, or as per customer request.
• MOQ: 1 kg
• Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
• Documentation: COA, MSDS, TDS, and additional testing reports available upon request.

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• LyvBio Co., Ltd. — Электронная почта: info@lyvbio.com