| Название продукта | Sunifiram |
| Синонимы | DM-235; DM235; 1-Benzoyl-4-propanoylpiperazine; 1-(4-Benzoylpiperazin-1-yl)propan-1-one; 1-Benzoyl-4-(1-oxopropyl)piperazine |
| Номер CAS | 314728-85-3 |
| Молекулярная формула | C₁₄H₁₈N₂O₂ |
| Молекулярная масса | 246.30 g/mol |
| Внешний вид | Кристаллический порошок от белого до небелого цвета |
| Анализ (ВЭЖХ) | ≥ 99,01 TP3T |
| Температура плавления | 86–89°C |
| Потери при сушке | ≤ 0,51 TP3T |
| Остаток после прокаливания | ≤ 0,11 TP3T |
| Тяжелые металлы | ≤ 10 ppm |
| Хранение | В прохладном, сухом, герметичном месте, защищенном от света |
| Срок годности | 36 месяцев |
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Sunifiram (developmental code DM-235) is a мощное ноотропное соединение belonging to the piperazine class.
It was developed as a next-generation cognitive enhancer with significantly higher potency than the classic racetam family (piracetam, aniracetam).
Sunifiram is structurally distinct from racetams but shares similar glutamatergic mechanisms.
Sunifiram is estimated to be примерно в 1 000 раз сильнее, чем пирацетам на моделях животных.
It acts as a positive allosteric modulator of AMPA receptors and may also influence nicotinic acetylcholine receptors (nAChRs).
Unlike many racetams, sunifiram does not require metabolic activation.
Sunifiram Nootropic Supplement
Sunifiram was developed by researchers at the University of Florence, Italy, as part of a series of potent ampakine-like compounds. Along with Unifiram (DM-232), it was designed to overcome the low potency limitations of traditional racetams. Preclinical studies demonstrated cognitive-enhancing effects at microgram-per-kilogram doses—orders of magnitude lower than piracetam (which requires milligram-per-kilogram doses).
Sunifiram exerts its effects primarily through glutamatergic modulation:
| Маршрут | Proposed Mechanism | Cognitive Effect |
|---|---|---|
| AMPA receptor positive allosteric modulation | Enhances glutamate-induced currents; increases synaptic plasticity | Memory consolidation, learning, attention |
| Nicotinic acetylcholine receptor (nAChR) modulation | May influence α7 nAChR subtypes (preliminary) | Focus, working memory |
| Cholinergic enhancement | Indirect (via glutamatergic-cholinergic interaction) | Learning, memory |
| Приложение | Описание | Конечные пользователи |
|---|---|---|
| AMPA receptor research | Studying positive allosteric modulation of AMPA receptors | Academic neuroscience, pharmacology labs |
| Cognitive enhancement studies | In vitro and animal models of memory, learning, attention | Behavioral neuroscience research |
| Scopolamine-induced amnesia models | Reversal of cholinergic deficit (Alzheimer’s research models) | Neuropharmacology, drug discovery |
| Comparative nootropic research | Potency comparisons with racetams and other ampakines | Фармацевтические исследования и разработки |
| Направления исследований | Приложение |
|---|---|
| Piperazine vs. pyrrolidone scaffolds | Comparing structural requirements for AMPA modulation |
| Derivative synthesis | Developing novel sunifiram analogs with improved properties |
| Receptor binding studies | Characterizing AMPA receptor subtype selectivity |
| Приложение | Описание |
|---|---|
| Эталонный стандарт | HPLC, LC-MS method development |
| Impurity profiling | For custom synthesis quality control |
| Stability studies | Forced degradation, long-term stability |
LyvBio Co., Ltd. is a GMP-certified supplier of high-purity Sunifiram for research and development applications.
Возможности поставок:
Анализ (ВЭЖХ): ≥99,01 TP3T
Форма: Кристаллический порошок
Ежемесячная производительность: 5 и более кг
Большие объемы: 1g – 5kg
Время выполнения: 3-5 дней (образцы), 10-15 дней (опт)
Документация: COA, MSDS,HNMR, HPLC chromatogram, stability data
Обеспечение качества:
Чистота по данным ВЭЖХ с УФ-детектированием
Проведенные испытания на остаточные растворители (соответствует стандарту USP )
Проанализированные тяжелые металлы (ICP-MS)
Подтверждение структуры (ЯМР — по запросу)
📧 Спрашивает: info@lyvbio.com
| Параметр | Технические характеристики | Метод испытания |
|---|---|---|
| Анализ (ВЭЖХ) | ≥ 99,01 TP3T | HPLC-UV (254 nm) |
| Внешний вид | Кристаллический порошок от белого до небелого цвета | Визуальный |
| Идентификация | Время удержания при ВЭЖХ, ЯМР (по запросу) | ВЭЖХ / ЯМР |
| Температура плавления | 86–89°C | USP |
| Потери при сушке | ≤ 0,51 TP3T | USP |
| Остаток после прокаливания | ≤ 0,11 TP3T | USP |
| Тяжелые металлы | Pb ≤ 10 ppm; As ≤ 2 ppm; Cd ≤ 1 ppm; Hg ≤ 0,1 ppm | ICP-MS |
| Схожие вещества | Содержание отдельных примесей ≤ 0,51 TP3T; общее содержание примесей ≤ 1,01 TP3T | ВЭЖХ-УФ |
| Остаточные растворители | Ознакомьтесь со стандартом USP | GC |
| Размер частиц | от 95% до 80 меш | Анализ по ситам |
Q: Is Sunifiram the same as Piracetam or Aniracetam?
A: No. Sunifiram is a structurally distinct piperazine derivative, not a racetam. It is estimated to be approximately 1,000 times more potent than piracetam in animal models.
Q: Is Sunifiram FDA-approved for medical use?
A: Нет. Sunifiram has no approved medical use in any major market. It is a research chemical for laboratory use only. No human clinical trials have been published.
Q: What is the difference between Sunifiram and Unifiram (DM-232)?
A: Both are piperazine derivatives developed by the same research group. They have similar potency (~1,000x piracetam) but different chemical structures (different substituents on the piperazine ring). Unifiram is CAS 219694-40-3.
Q: What is the mechanism of action of Sunifiram?
A: Sunifiram is believed to act as a positive allosteric modulator of AMPA receptors (an ampakine). It may also influence nicotinic acetylcholine receptors. Detailed receptor binding studies are limited.
Вопрос: Каков диапазон эффективных доз в исследованиях на животных?
A: Published studies report cognitive-enhancing effects at 0.01–0.1 mg/kg (oral) in rodents—approximately 1,000 times more potent than piracetam.
Q: Are there human clinical trials for Sunifiram?
A: Нет. No human clinical trials have been published. Sunifiram is a research chemical only.
📧 Электронная почта: info@lyvbio.com
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