Sitagliptin

Synonyms

• Sitagliptin phosphate, MK-0431, Januvia, Ristaben, Tesavel, Xelevia, Sitagliptin base

Sitagliptin is one of the most widely prescribed DPP-4 inhibitors on the market, and for good reason: it helps type 2 diabetes patients manage blood glucose without the dramatic peaks and troughs that come with some older therapies. By selectively blocking the DPP-4 enzyme, it extends the half-life of incretin hormones like GLP-1, which in turn boosts insulin release when glucose is high and keeps glucagon secretion in check. The result is a smoother, more physiological control of post-meal blood sugar—exactly what clinicians and patients are looking for.

We supply sitagliptin as a high-purity API (≥99% by HPLC) in its base form, ideal for formulation into oral tablets or combination therapies. Every batch is manufactured under strict quality controls and shipped with a complete COA, so you know exactly what you’re getting. Whether you’re planning a small pilot run or gearing up for commercial-scale production, we can match your volume—from 1 kg to metric tons—with reliable lead times and global logistics.

Function

• DPP-4 Inhibition: Selective and reversible inhibition of the dipeptidyl peptidase-4 enzyme, increasing active GLP-1 and GIP levels.
• Glucose-Dependent Insulin Release: Enhances insulin secretion only when blood glucose is elevated, reducing the risk of hypoglycemia.
• Glucagon Regulation: Suppresses glucagon secretion, further helping to lower hepatic glucose output.

Source & Purity

• Purity: ≥99% (HPLC), meeting or exceeding pharmacopoeia standards for sitagliptin API.
• Appearance: White to off-white crystalline powder, consistent with high-quality API.
• Stability: Stable under recommended storage conditions; shelf life confirmed by stability studies.

Documentation & Supply

• Documentation: COA, MSDS, TDS
• Lead time: Ready stock for samples; 7-15 days for bulk orders, depending on volume.
• Packaging: Available in double-layer polyethylene bags inside fiber drums (1-25 kg), or customized packaging per your request.

Request For Quote

• Our Address: 280 Main Street, Xian, Shaanxi, China
• LyvBio Co., Ltd. — Email: info@lyvbio.com