Kaempferol

Kaempferol

Product Name Kaempferol
Synonyms 3,4',5,7-Tetrahydroxyflavone;

Robigenin;

Pelargidenolon;

Kaempferide

CAS Number 520-18-3
Molecular Formula C₁₅H₁₀O₆
Molecular Weight 286.24 g/mol
EINECS Number 208-287-6
Appearance Yellow to greenish-yellow crystalline powder
Assay (HPLC) ≥ 98.0%
Loss on Drying ≤ 1.0%

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Kaempferol is a naturally occurring flavonol belonging to the flavonoid class of polyphenolic compounds.

It is widely distributed in the plant kingdom, found in a variety of dietary sources including tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries, and grapes.

It is also present in medicinal plants such as Ginkgo biloba and Sophora japonica.

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Kaempferol has been extensively studied for its potential in cardiovascular protection, neuroprotection, metabolic health, and cancer chemoprevention.

Its mechanisms include activation of Nrf2, inhibition of NF-κB, and modulation of PI3K/Akt and MAPK pathways.

As one of the most abundant dietary flavonoids, kaempferol is recognized as a promising bioactive compound for health promotion and disease prevention.

Function

  • Potent antioxidant: Directly scavenges ROS and chelates transition metals.

  • Cardiovascular support: Improves endothelial function, reduces oxidative stress in vascular tissues.

  • Neuroprotective activity: Protects neurons from oxidative damage and supports cognitive function.

  • Metabolic regulation: Modulates glucose and lipid metabolism via AMPK activation.

 Purity

  • Standardization: ≥98.0% kaempferol (HPLC)

  • Forms: Crystalline powder (aglycone)

  • Applications: Dietary supplements, pharmaceutical research, analytical standards, cosmetic formulations

Related Compounds

Compound CAS No. Key Application Relationship
Kaempferol 520-18-3 Antioxidant, cardiovascular, neuroprotection Parent compound
Quercetin 117-39-5 Antioxidant, immune support, cardiovascular Flavonol analogue (one more OH group)
Myricetin 529-44-2 Antioxidant, metabolic health Flavonol analogue (three OH groups)
Kaempferol-3-O-glucoside (Astragalin) 480-10-4 Antioxidant, anti-inflammatory Glycosylated derivative
Rutin 153-18-4 Antioxidant, vascular support Flavonol glycoside

Spec

Parameter Specification
Kaempferol Content (HPLC) ≥ 98.0%
Identification UV-Vis / IR spectrum conforms to reference
Melting Point 276 – 278°C
Loss on Drying ≤ 1.0%
Residue on Ignition ≤ 0.5%
Heavy Metals (as Pb) ≤ 10 ppm
Arsenic (As) ≤ 1 ppm

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