Clorsulon

Clorsulon

Parameter Specification
Product Name Clorsulon
CAS Number 60200-06-8
Molecular Formula C8H8Cl3N3O4S2
Molecular Weight 380.66 g/mol
Appearance White to off-white crystalline powder
Assay (HPLC) ≥98.0%
Solubility Slightly soluble in water, soluble in methanol, ethanol
Package 25 kg fiber drum with double polyethylene liner

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Clorsulon Structure

Synonyms: 4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, MK-401, Clorsulonum, 4-Amino-6-(trichlorovinyl)-m-benzenedisulfonamide

Clorsulon is a benzenesulfonamide derivative characterized by a trichloroethenyl group and two sulfonamide moieties. This unique structure enables it to inhibit key enzymes in the glycolytic pathway of parasitic flukes, particularly phosphoglycerate kinase and phosphoglyceromutase, disrupting energy production in susceptible organisms.

First developed for veterinary medicine, Clorsulon is primarily used to treat liver fluke infections in cattle and sheep. It is available as a high-purity active pharmaceutical ingredient (API) with a minimum assay of 98.0%, meeting stringent quality standards for pharmaceutical and research applications.

In addition to its veterinary use, Clorsulon serves as a reference standard and is investigated for its potential in other therapeutic areas. Its well-defined mechanism and favorable safety profile make it a valuable compound for both veterinary and pharmaceutical research.

Chemical Structure & Properties

Clorsulon belongs to the sulfonamide class and features a benzene ring substituted with an amino group, a trichloroethenyl group, and two sulfonamide groups. It appears as a white to off-white crystalline powder, slightly soluble in water but soluble in organic solvents like methanol and ethanol. The compound is stable under normal storage conditions and exhibits good thermal stability.

Mechanism of Action

  • Enzyme inhibition: Inhibits phosphoglycerate kinase and phosphoglyceromutase, disrupting glycolysis in flukes.
  • Energy depletion: Leads to ATP depletion and subsequent death of the parasite.
  • Selective toxicity: High efficacy against Fasciola species with low toxicity to mammalian hosts.
  • Synergistic potential: Often used in combination with other anthelmintics for broader spectrum activity.

Quality Specifications (QC Tests)

Test Item Specification
Identification IR spectrum consistent with reference standard
Loss on Drying ≤0.5%
Residue on Ignition ≤0.1%
Heavy Metals ≤20 ppm
Related Substances Any individual impurity ≤0.5%, total impurities ≤1.0%
Microbial Limits Total aerobic count ≤1000 CFU/g, yeast and mold ≤100 CFU/g

Supply & Documentation

  • Capacity: 5 metric tons per month
  • Lead time: 3-5 business days (stock items)
  • Documentation: COA, MSDS, TDS available upon request
  • Packaging: 25 kg fiber drum with double polyethylene liner

Frequently Asked Questions

What is the minimum order quantity for Clorsulon?

We supply Clorsulon in quantities starting from 1 kg. For larger orders, please contact us for pricing and availability.

What is the delivery time?

For stock items, delivery is typically within 3-5 business days after order confirmation.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, we provide a COA for each batch. Samples are available upon request; please contact our sales team for arrangements.

Contact & Ordering Information

  • Company: LyvBio Co., Ltd.
  • Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
  • Email: info@lyvbio.com
  • Phone: +86-29-65816888

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