Clorsulon

Synonyme: 4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, MK-401, Clorsulonum, 4-Amino-6-(trichlorovinyl)-m-benzenedisulfonamide

Clorsulon is a benzenesulfonamide derivative characterized by a trichloroethenyl group and two sulfonamide moieties. This unique structure enables it to inhibit key enzymes in the glycolytic pathway of parasitic flukes, particularly phosphoglycerate kinase and phosphoglyceromutase, disrupting energy production in susceptible organisms.

First developed for veterinary medicine, Clorsulon is primarily used to treat liver fluke infections in cattle and sheep. It is available as a high-purity active pharmaceutical ingredient (API) with a minimum assay of 98.0%, meeting stringent quality standards for pharmaceutical and research applications.

In addition to its veterinary use, Clorsulon serves as a reference standard and is investigated for its potential in other therapeutic areas. Its well-defined mechanism and favorable safety profile make it a valuable compound for both veterinary and pharmaceutical research.

Chemical Structure & Properties

Clorsulon belongs to the sulfonamide class and features a benzene ring substituted with an amino group, a trichloroethenyl group, and two sulfonamide groups. It appears as a white to off-white crystalline powder, slightly soluble in water but soluble in organic solvents like methanol and ethanol. The compound is stable under normal storage conditions and exhibits good thermal stability.

Mechanism of Action

• Enzyme inhibition: Inhibits phosphoglycerate kinase and phosphoglyceromutase, disrupting glycolysis in flukes.
• Energy depletion: Leads to ATP depletion and subsequent death of the parasite.
• Selective toxicity: High efficacy against Fasciola species with low toxicity to mammalian hosts.
• Synergistic potential: Often used in combination with other anthelmintics for broader spectrum activity.

Quality Specifications (QC Tests)

Supply & Documentation

• Capacity: 5 metric tons per month
• Lieferzeit: 3–5 Werktage (Lagerware)
• Dokumentation: COA, MSDS, TDS available upon request
• Verpackung: 25 kg fiber drum with double polyethylene liner

Häufig gestellte Fragen

What is the minimum order quantity for Clorsulon?

We supply Clorsulon in quantities starting from 1 kg. For larger orders, please contact us for pricing and availability.

What is the delivery time?

For stock items, delivery is typically within 3-5 business days after order confirmation.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, we provide a COA for each batch. Samples are available upon request; please contact our sales team for arrangements.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.