Sodium Taurocholate Hydrate
| Nazwa produktu | Sodium Taurocholate Hydrate |
|---|---|
| Numer CAS | 345909-26-4 |
| Wzór cząsteczkowy | C26H44NNaO7S · xH2O |
| Masa cząsteczkowa | 537.68 g/mol (anhydrous basis) |
| Wygląd | Biały lub prawie biały krystaliczny proszek |
| Oznaczenie (HPLC) | ≥98,01 TP3T |
| Rozpuszczalność | Soluble in water and ethanol; practically insoluble in non-polar solvents |
| Strata przy suszeniu | ≤8.0% (hydrate form) |
| Przechowywanie | Store in a cool, dry place, protected from light |
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Synonimy: Taurocholic acid sodium salt hydrate, Sodium taurocholate, Taurocholic acid sodium salt, Sodium cholate tautaurate, Cholyltaurine sodium salt, Sodium 2-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]aminoethanesulfonate
Sodium Taurocholate Hydrate is the sodium salt of taurocholic acid, a primary bile acid conjugated with taurine, existing as a crystalline hydrate. It is a high-purity bile salt widely used as a biochemical surfactant and solubilizing agent in pharmaceutical and life science research. The product is typically manufactured through chemical synthesis or semi-synthesis from cholic acid, followed by conjugation with taurine and subsequent salt formation, yielding a stable hydrate form.
In the pharmaceutical and biotech industries, Sodium Taurocholate Hydrate serves as a critical excipient for enhancing the solubility and bioavailability of poorly water-soluble drugs, particularly in oral and injectable formulations. It is also a key component in cell culture media, where it facilitates lipid digestion and absorption, and finds use in membrane protein research as a mild detergent for solubilization and reconstitution. Its ability to form mixed micelles makes it indispensable in studies of bile acid metabolism, cholestasis, and drug transport mechanisms.
| Parametr | Specyfikacja |
|---|---|
| Oznaczenie (HPLC) | ≥98,01 TP3T |
| Wygląd | Biały lub prawie biały krystaliczny proszek |
| Rozpuszczalność | Soluble in water and ethanol |
| Strata przy suszeniu | ≤8.0% |
| Metale ciężkie | ≤10 ppm |
| Przechowywanie | Cool, dry, protected from light |
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