Lamotrigine

Sinonimi: 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, Lamictal, LTG, BW-430C, 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine

Lamotrigine is a phenyltriazine derivative that has carved out a distinct place in the anticonvulsant and mood-stabilizer markets since its approval in the 1990s. Unlike older antiepileptics that emerged from serendipitous screening, lamotrigine was designed to inhibit glutamate release—a mechanism that translates into broad-spectrum efficacy across partial and generalized seizures. For procurement teams, it represents a reliable, well-characterized API with steady demand from both generic and branded formulators.

From a chemical standpoint, lamotrigine is a small molecule (C9H7Cl2N5) with a dichlorophenyl ring attached to a diaminotriazine core. This structure gives it moderate lipophilicity and a low aqueous solubility, which formulators often address through salt formation or particle-size engineering. The compound is chemically stable under normal storage conditions, though it is light-sensitive and should be protected from prolonged exposure to strong UV light.

Manufacturing lamotrigine at commercial scale typically involves a multi-step synthesis starting from 2,3-dichlorobenzoyl chloride or related precursors. The critical quality attributes—assay, related substances, and residual solvents—are tightly controlled to meet pharmacopeial monographs (USP, EP, BP). Our material is produced under cGMP conditions and is available with full regulatory support, including DMF and CEP where applicable.

While lamotrigine is best known for epilepsy, its use in bipolar disorder—particularly for delaying depressive episodes—has expanded its clinical footprint. This dual indication keeps demand stable across multiple therapeutic categories, making it a strategic API for companies serving both neurology and psychiatry markets.

Funzione

• Anticonvulsant activity: Blocks voltage-gated sodium channels, stabilizing neuronal membranes and reducing seizure spread.
• Glutamate inhibition: Suppresses excessive glutamate release, which contributes to its broad-spectrum efficacy.
• Mood stabilization: Effective in delaying depressive episodes in bipolar I disorder, likely through limbic system modulation.
• Neuroprotective potential: Under investigation for conditions involving glutamate excitotoxicity, such as neuropathic pain.

Fonte e standardizzazione

• Fonte: Synthetic chemical synthesis (not botanical)
• Standardizzazione: Complies with USP/EP/BP monographs; assay 98.0–102.0% (HPLC)
• Moduli: White to off-white crystalline powder
• Applicazioni: Antiepileptic and mood-stabilizer finished dosage forms

Caratteristiche tecniche

Documentazione e forniture

• Capacità mensile: 2–3 metric tons
• Tempi di consegna: 3-5 business days (stock items)
• Documentazione: COA, MSDS, TDS, DMF (where applicable), stability data
• Confezionamento: 25 kg fiber drum with double polyethylene liner, or as requested

Richiesta di preventivo

• LyvBio S.r.l. — E-mail: info@lyvbio.com