Niclosamide

Synonymes : 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, 2′,5-Dichloro-4′-nitrosalicylanilide, Niclosamide, Niclocide, Yomesan, Bayluscid, Cestocid

Niclosamide has seen a notable resurgence in demand — not only as a long-established anthelmintic but also as a candidate molecule in antiviral and oncology research. Its ability to interfere with multiple signaling pathways has made it a staple in drug repurposing libraries, while its proven efficacy against tapeworm infections keeps it firmly on the WHO Essential Medicines List. For procurement teams, this dual identity means steady interest from both generic pharmaceutical manufacturers and research-driven organizations.

The compound is a salicylanilide derivative, chemically defined as 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide. It appears as a pale yellow crystalline powder, practically insoluble in water but freely soluble in polar aprotic solvents such as DMSO and DMF. This solubility profile is a key consideration during formulation, particularly for oral solid dosage forms where particle size and polymorphic form can influence dissolution.

LyvBio supplies Niclosamide with a minimum assay of 98.0% by HPLC, produced under cGMP-compliant conditions. Each batch is tested for identity, purity, residual solvents, and heavy metals, and is accompanied by a full Certificate of Analysis. The material is offered in kilogram to multi-tonne quantities, with stock readily available for immediate dispatch.

Présentation et composition du produit

Niclosamide is a synthetic salicylanilide, structurally featuring a 2-hydroxybenzamide core with chlorine and nitro substituents on the aniline ring. This arrangement is responsible for its protonophoric activity — the molecule can shuttle protons across mitochondrial membranes, disrupting energy metabolism in susceptible organisms. The same mechanism underlies much of its investigational activity in mammalian cells, including inhibition of STAT3, Wnt/β-catenin, and mTOR pathways.

Commercial Niclosamide is typically manufactured via condensation of 5-chlorosalicylic acid with 2-chloro-4-nitroaniline, followed by purification and crystallization. The final product is a single chemical entity, not a mixture of isomers, and is standardized to a minimum of 98% purity. It contains no excipients or carriers unless a specific formulated grade is requested.

Applications & Product Lines

• Anthelmintic pharmaceuticals: Niclosamide is the active ingredient in human and veterinary tapeworm treatments, often formulated as chewable tablets or suspension.
• Antiviral research: Investigated for its broad-spectrum activity against SARS-CoV-2, Zika, and influenza viruses, primarily in in vitro and early-stage preclinical models.
• Oncology research: Explored as a repurposed agent targeting cancer stem cells and drug-resistant tumor lines, frequently used in combination studies.
• Molluscicide formulations: Applied in public health programs to control snail populations that transmit schistosomiasis.
• Reference standards and analytical testing: Used as a certified reference material for method development and quality control in contract laboratories.

Quality Control Standards

Bulk Packaging & Supply

• Emballage: 25 kg fiber drums with double polyethylene liners; custom packaging available upon request.
• Quantité minimale de commande: 1 kg for stock items; 25 kg for custom or bulk orders.
• Délai de livraison: 3-5 business days from order confirmation for stock items.
• Documentation: Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), Technical Data Sheet (TDS), and cGMP statement provided with each shipment.

Foire aux questions

What is the minimum order quantity for Niclosamide?

Our MOQ is 1 kg for stock material, though we recommend 25 kg for commercial-scale production to ensure batch consistency and cost efficiency.

How long does delivery take?

For items held in stock, we ship within 3-5 business days after order confirmation. Custom or bulk orders may require additional time, which we confirm at the quotation stage.

Do you provide a COA and samples?

Yes, a full COA is issued for every batch. Samples of 10-50 g are available for evaluation and are typically dispatched within 1-2 days of request.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.