Niclosamide
| パラメータ | 仕様 |
|---|---|
| 製品名 | Niclosamide |
| CAS番号 | 50-65-7 |
| 分子式 | C13H8Cl2N2O4 |
| 分子量 | 327.12 g/mol |
| 外観 | Pale yellow to yellow crystalline powder |
| 分析（HPLC） | ≥98.0% |
| 溶解度 | Sparingly soluble in water; soluble in dimethyl sulfoxide, dimethylformamide; slightly soluble in ethanol, acetone |
| パッケージ | 25 kg fiber drum with double polyethylene liner |
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同義語： 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, 2′,5-Dichloro-4′-nitrosalicylanilide, Niclosamide, Niclocide, Yomesan, Bayluscid, Cestocid
Niclosamide has seen a notable resurgence in demand — not only as a long-established anthelmintic but also as a candidate molecule in antiviral and oncology research. Its ability to interfere with multiple signaling pathways has made it a staple in drug repurposing libraries, while its proven efficacy against tapeworm infections keeps it firmly on the WHO Essential Medicines List. For procurement teams, this dual identity means steady interest from both generic pharmaceutical manufacturers and research-driven organizations.
The compound is a salicylanilide derivative, chemically defined as 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide. It appears as a pale yellow crystalline powder, practically insoluble in water but freely soluble in polar aprotic solvents such as DMSO and DMF. This solubility profile is a key consideration during formulation, particularly for oral solid dosage forms where particle size and polymorphic form can influence dissolution.
LyvBio supplies Niclosamide with a minimum assay of 98.0% by HPLC, produced under cGMP-compliant conditions. Each batch is tested for identity, purity, residual solvents, and heavy metals, and is accompanied by a full Certificate of Analysis. The material is offered in kilogram to multi-tonne quantities, with stock readily available for immediate dispatch.
Niclosamide is a synthetic salicylanilide, structurally featuring a 2-hydroxybenzamide core with chlorine and nitro substituents on the aniline ring. This arrangement is responsible for its protonophoric activity — the molecule can shuttle protons across mitochondrial membranes, disrupting energy metabolism in susceptible organisms. The same mechanism underlies much of its investigational activity in mammalian cells, including inhibition of STAT3, Wnt/β-catenin, and mTOR pathways.
Commercial Niclosamide is typically manufactured via condensation of 5-chlorosalicylic acid with 2-chloro-4-nitroaniline, followed by purification and crystallization. The final product is a single chemical entity, not a mixture of isomers, and is standardized to a minimum of 98% purity. It contains no excipients or carriers unless a specific formulated grade is requested.
| Test Item | 仕様 |
|---|---|
| 識別 | IR spectrum conforms to reference standard; HPLC retention time matches |
| 乾燥減量 | ≤0.5% |
| 焼失残渣 | ≤0.11 TP3T |
| 重金属 | ≤20 ppm |
| Organic Impurities | Any individual impurity ≤0.5%; total impurities ≤2.0% |
| 残留溶剤 | Meets ICH Q3C limits |
| Microbial Limits | Total aerobic count ≤1000 CFU/g; yeast and mould ≤100 CFU/g; absence of E. coli and Salmonella |
Our MOQ is 1 kg for stock material, though we recommend 25 kg for commercial-scale production to ensure batch consistency and cost efficiency.
For items held in stock, we ship within 3-5 business days after order confirmation. Custom or bulk orders may require additional time, which we confirm at the quotation stage.
Yes, a full COA is issued for every batch. Samples of 10-50 g are available for evaluation and are typically dispatched within 1-2 days of request.
send us your specification for a quotation.
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