Abamectin

Synonymes : Avermectin B1, Abamectine, MK-936, Avid, Zephyr, Vertimec, Agri-Mek, Dynamec

Abamectin is a macrocyclic lactone of the avermectin family, built on a 16-membered ring fused to a spiroketal system and a disaccharide side chain. This structural arrangement is responsible for its potent binding affinity to invertebrate glutamate-gated chloride channels (GluCls), a target that does not exist in mammals at the same level. The two homologous components, B1a and B1b, differ by a single methylene group and typically occur in a ratio of about 80:20, which is reflected in the commercial standard.

Produced through fermentation of Streptomyces avermitilis and purified to a defined B1a/B1b ratio, Abamectin is supplied as a technical-grade active ingredient for formulation into veterinary parasiticides, crop protection products, and research reference standards. It is not a single pure compound but a well-characterized mixture, and buyers generally specify the total B1 content along with the B1a to B1b ratio.

For B2B customers, Abamectin remains a workhorse in antiparasitic portfolios. Its broad-spectrum activity against nematodes, arthropods, and insects, combined with a favorable mammalian safety profile when used as directed, keeps demand steady across animal health and agrochemical sectors. The sections below cover the key technical and supply details.

Structure chimique et propriétés

Abamectin consists of a macrocyclic lactone core with a spiroketal moiety and a disaccharide substituent at C-13. The B1a component carries a sec-butyl group at C-25, while B1b has an isopropyl group; this minor difference affects lipophilicity and target binding kinetics. The molecule is practically insoluble in water but dissolves readily in most organic solvents such as methanol, acetone, and dichloromethane. It is sensitive to light and oxidizing conditions, so handling and storage should protect against these factors. The material is typically supplied as a white to off-white crystalline powder with a characteristic UV absorption maximum around 245 nm.

Mécanisme d'action

• Glutamate-gated chloride channel activation: Abamectin binds to GluCls in invertebrate nerve and muscle cells, causing an influx of chloride ions and hyperpolarization.
• Paralysis and death: The resulting inhibition of neuronal signaling leads to paralysis, feeding cessation, and eventual death of the parasite or pest.
• Selectivity: Mammalian GABA receptors are less sensitive to abamectin, and the blood-brain barrier limits central nervous system exposure, contributing to its safety margin in target species.
• Broad-spectrum activity: Effective against a range of nematodes, mites, and insects, including those resistant to other classes.

Quality Specifications (QC Tests)

Approvisionnement et documentation

• Capacité: 500 kg per month
• Délai de livraison: 3 à 5 jours ouvrés (articles en stock)
• Documentation: Certificat d'analyse (COA), fiche de données de sécurité (FDS) et fiche technique (TDS) disponibles sur demande
• Emballage: 1 kg, 5 kg, 25 kg fiber drums with inner polyethylene bags

Foire aux questions

What is the minimum order quantity (MOQ)?

Our standard MOQ is 1 kg, but we can accommodate smaller quantities for research and development purposes. Please contact us for specific requirements.

What is the delivery time?

For stock items, delivery is typically 3-5 business days from order confirmation.

Can you provide a COA and sample?

Yes, we provide a COA for every batch and can supply samples for evaluation. Sample requests are usually processed within 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.