Oxfendazole

Sinónimos: Methyl 5-(phenylsulfinyl)-1H-benzimidazol-2-ylcarbamate, Fenbendazole sulfoxide, Oxfendazole, HOE 8105, Synanthic, 53716-50-0

Oxfendazole is a benzimidazole anthelmintic developed as the sulfoxide metabolite of fenbendazole. It is a white to off-white crystalline powder, practically insoluble in water but soluble in polar aprotic solvents like dimethylformamide and dimethyl sulfoxide. Since its introduction in the 1970s, it has been used extensively in veterinary medicine to control gastrointestinal nematodes, lungworms, and tapeworms in cattle, sheep, and swine. Its efficacy against a broad spectrum of parasites, including benzimidazole-resistant strains, has made it a reliable choice for livestock deworming programs.

Chemically, oxfendazole belongs to the benzimidazole carbamate family. Its structure features a phenylsulfinyl group at the 5-position of the benzimidazole ring, which enhances its anthelmintic activity compared to fenbendazole. The compound acts by binding to β-tubulin, inhibiting microtubule polymerization and disrupting cellular processes in parasites. This mechanism is shared with other benzimidazoles, but oxfendazole’s sulfoxide moiety improves its pharmacokinetic profile, leading to higher plasma concentrations and prolonged efficacy.

In the pharmaceutical industry, oxfendazole is standardized to high purity, typically ≥98% as determined by HPLC. It is primarily used as an active pharmaceutical ingredient (API) in veterinary formulations, including oral suspensions, boluses, and feed premixes. Its broad-spectrum activity and favorable safety profile in target animals make it a key component in parasite control strategies. Additionally, oxfendazole is sometimes employed as a reference standard in analytical laboratories and for research purposes.

Function & Mechanism

• Anthelmintic activity: Binds to β-tubulin, inhibiting microtubule assembly and causing parasite immobilization and death.
• Broad-spectrum efficacy: Effective against adult and immature stages of gastrointestinal nematodes, lungworms, and tapeworms.
• Ovicidal effect: Reduces egg viability and fecal egg counts, helping to control pasture contamination.
• Metabolic stability: The sulfoxide group enhances systemic availability and prolongs anthelmintic action.
• Safety margin: Well-tolerated in cattle, sheep, and swine at recommended doses.

Source & Standardization

• Source: Synthetic chemical, derived from fenbendazole through oxidation.
• Manufacturing: Chemical synthesis followed by purification and crystallization.
• Standardization: ≥98.0% oxfendazole (HPLC).
• Forms: White to off-white crystalline powder.
• Aplicaciones: Veterinary anthelmintic formulations, research, reference standard.

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Monthly capacity: 5 metric tons
• Plazo de entrega: 3-5 días laborables (artículos en stock)
• Documentación: Certificado de análisis (COA), ficha de datos de seguridad (MSDS) y ficha técnica del producto (TDS) disponibles previa solicitud
• Embalaje: 25 kg fiber drum with double polyethylene liner

Preguntas frecuentes

What is the minimum order quantity (MOQ) for Oxfendazole?

Our standard MOQ is 25 kg. For smaller quantities, please contact us to discuss your specific requirements.

How long does delivery take?

For stock items, delivery is typically 3-5 business days after order confirmation.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, we provide a COA for each batch. Samples are available upon request for quality evaluation.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.