| Nombre del producto | Sunifiram |
| Sinónimos | DM-235; DM235; 1-Benzoyl-4-propanoylpiperazine; 1-(4-Benzoylpiperazin-1-yl)propan-1-one; 1-Benzoyl-4-(1-oxopropyl)piperazine |
| Número CAS | 314728-85-3 |
| Fórmula molecular | C₁₄H₁₈N₂O₂ |
| Peso molecular | 246.30 g/mol |
| Apariencia | Polvo cristalino de color blanco a blanquecino |
| Ensayo (HPLC) | ≥ 99,01 TP3T |
| Punto de fusión | 86–89°C |
| Pérdida por secado | ≤ 0,51 TP3T |
| Residuo tras la combustión | ≤ 0,11 TP3T |
| Metales pesados | ≤ 10 ppm |
| Almacenamiento | En un lugar fresco, seco, hermético y protegido de la luz |
| Vida útil | 36 meses |
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Sunifiram (developmental code DM-235) is a potente compuesto nootrópico belonging to the piperazine class.
It was developed as a next-generation cognitive enhancer with significantly higher potency than the classic racetam family (piracetam, aniracetam).
Sunifiram is structurally distinct from racetams but shares similar glutamatergic mechanisms.
Sunifiram is estimated to be aproximadamente 1.000 veces más potente que el piracetam en modelos animales.
It acts as a positive allosteric modulator of AMPA receptors and may also influence nicotinic acetylcholine receptors (nAChRs).
Unlike many racetams, sunifiram does not require metabolic activation.
Sunifiram Nootropic Supplement
Sunifiram was developed by researchers at the University of Florence, Italy, as part of a series of potent ampakine-like compounds. Along with Unifiram (DM-232), it was designed to overcome the low potency limitations of traditional racetams. Preclinical studies demonstrated cognitive-enhancing effects at microgram-per-kilogram doses—orders of magnitude lower than piracetam (which requires milligram-per-kilogram doses).
Sunifiram exerts its effects primarily through glutamatergic modulation:
| Itinerario | Proposed Mechanism | Cognitive Effect |
|---|---|---|
| AMPA receptor positive allosteric modulation | Enhances glutamate-induced currents; increases synaptic plasticity | Memory consolidation, learning, attention |
| Nicotinic acetylcholine receptor (nAChR) modulation | May influence α7 nAChR subtypes (preliminary) | Focus, working memory |
| Cholinergic enhancement | Indirect (via glutamatergic-cholinergic interaction) | Learning, memory |
| Solicitud | Descripción | Usuarios finales |
|---|---|---|
| AMPA receptor research | Studying positive allosteric modulation of AMPA receptors | Academic neuroscience, pharmacology labs |
| Cognitive enhancement studies | In vitro and animal models of memory, learning, attention | Behavioral neuroscience research |
| Scopolamine-induced amnesia models | Reversal of cholinergic deficit (Alzheimer’s research models) | Neuropharmacology, drug discovery |
| Comparative nootropic research | Potency comparisons with racetams and other ampakines | Investigación y desarrollo farmacéutico |
| Research Focus | Solicitud |
|---|---|
| Piperazine vs. pyrrolidone scaffolds | Comparing structural requirements for AMPA modulation |
| Derivative synthesis | Developing novel sunifiram analogs with improved properties |
| Receptor binding studies | Characterizing AMPA receptor subtype selectivity |
| Solicitud | Descripción |
|---|---|
| Reference standard | HPLC, LC-MS method development |
| Impurity profiling | For custom synthesis quality control |
| Stability studies | Forced degradation, long-term stability |
LyvBio S.L. is a GMP-certified supplier of high-purity Sunifiram for research and development applications.
Capacidad de suministro:
Ensayo (HPLC): ≥99,01 TP3T
Formulario: Polvo cristalino
Capacidad mensual: 5+ kg
Cantidades al por mayor: 1g – 5kg
Plazo de entrega: 3-5 días (muestras), 10-15 días (a granel)
Documentación: COA, MSDS,HNMR, HPLC chromatogram, stability data
Control de calidad:
Pureza determinada por HPLC con detección UV
Se han analizado los disolventes residuales (cumple con la norma USP )
Metales pesados analizados (ICP-MS)
Confirmación estructural (RMN previa solicitud)
📧 Consultas: info@lyvbio.com
| Parámetro | Especificaciones | Método de ensayo |
|---|---|---|
| Ensayo (HPLC) | ≥ 99,01 TP3T | HPLC-UV (254 nm) |
| Apariencia | Polvo cristalino de color blanco a blanquecino | Visual |
| Identificación | Tiempo de retención por HPLC, RMN (bajo pedido) | HPLC / RMN |
| Punto de fusión | 86–89°C | USP |
| Pérdida por secado | ≤ 0,51 TP3T | USP |
| Residuo tras la combustión | ≤ 0,11 TP3T | USP |
| Metales pesados | Pb ≤ 10 ppm; As ≤ 2 ppm; Cd ≤ 1 ppm; Hg ≤ 0,1 ppm | ICP-MS |
| Sustancias relacionadas | Impureza individual ≤ 0,51 TP3T; Total ≤ 1,01 TP3T | HPLC-UV |
| Disolventes residuales | Conoce la norma USP | GC |
| Tamaño de las partículas | De 95% a malla 80 | Análisis granulométrico |
Q: Is Sunifiram the same as Piracetam or Aniracetam?
A: No. Sunifiram is a structurally distinct piperazine derivative, not a racetam. It is estimated to be approximately 1,000 times more potent than piracetam in animal models.
Q: Is Sunifiram FDA-approved for medical use?
R: No. Sunifiram has no approved medical use in any major market. It is a research chemical for laboratory use only. No human clinical trials have been published.
Q: What is the difference between Sunifiram and Unifiram (DM-232)?
A: Both are piperazine derivatives developed by the same research group. They have similar potency (~1,000x piracetam) but different chemical structures (different substituents on the piperazine ring). Unifiram is CAS 219694-40-3.
Q: What is the mechanism of action of Sunifiram?
A: Sunifiram is believed to act as a positive allosteric modulator of AMPA receptors (an ampakine). It may also influence nicotinic acetylcholine receptors. Detailed receptor binding studies are limited.
P: ¿Cuál es el rango de dosis eficaz en los estudios con animales?
A: Published studies report cognitive-enhancing effects at 0.01–0.1 mg/kg (oral) in rodents—approximately 1,000 times more potent than piracetam.
Q: Are there human clinical trials for Sunifiram?
R: No. No human clinical trials have been published. Sunifiram is a research chemical only.
📧 Correo electrónico: info@lyvbio.com
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