Urolithin B

Synonyms: 3-Hydroxy-6H-dibenzo[b,d]pyran-6-one, 3-Hydroxyurolithin B, 3-Hydroxy-6H-benzo[c]chromen-6-one, 3-Hydroxy-6H-dibenzo[b,d]pyran-6-one, Urolithin B

Urolithin B is a gut microbiota-derived metabolite of ellagitannins, a class of hydrolyzable tannins found in pomegranates, walnuts, and berries. It belongs to the urolithin family, which are dibenzo[b,d]pyran-6-one derivatives formed through the sequential action of intestinal bacteria on ellagic acid. Urolithin B is one of the major urolithins detected in human plasma and urine after consumption of ellagitannin-rich foods, alongside urolithin A. While urolithin A has gained significant attention for its mitophagy-inducing properties, urolithin B is increasingly recognized for its distinct biological activities, particularly in muscle physiology and inflammation modulation.

From a chemical perspective, urolithin B (C13H8O3) is a hydroxylated dibenzo-pyranone with a molecular weight of 212.20 g/mol. It differs from urolithin A by the absence of a hydroxyl group at the 8-position, which influences its solubility, metabolic stability, and interaction with biological targets. This structural distinction underpins its unique pharmacological profile, including its ability to modulate androgen receptor signaling and inhibit NF-κB activation. Urolithin B is typically produced via chemical synthesis or through biotransformation of ellagic acid using microbial cultures, ensuring high purity and consistent supply for research and product development.

In the nutritional and pharmaceutical industries, urolithin B is explored for its potential in muscle health, anti-inflammatory applications, and as a reference standard for analytical methods. It is available at high purity grades (≥98% by HPLC) and is used in preclinical studies, dietary supplement formulations, and as a biomarker for gut microbial metabolism of polyphenols.

Function

• Muscle protein synthesis: Urolithin B has been shown to stimulate muscle hypertrophy and inhibit muscle protein breakdown in preclinical models.
• Anti-inflammatory activity: Inhibits NF-κB signaling and reduces pro-inflammatory cytokine production.
• Androgen receptor modulation: Acts as a selective androgen receptor modulator, enhancing anabolic effects in muscle tissue.
• Antioxidant defense: Scavenges free radicals and upregulates endogenous antioxidant enzymes.
• Gut microbiota metabolite: Serves as a biomarker for ellagitannin metabolism and gut health.

Source & Standardization

• Source: Chemical synthesis or microbial biotransformation of ellagic acid
• Extraction: Not applicable (synthetic or biotech-derived)
• Standardization: ≥98.0% (HPLC)
• Forms: Off-white to light yellow crystalline powder
• Applications: Dietary supplements, sports nutrition, research studies, analytical standards

Specifications

Documentation & Supply

• Monthly capacity: 50 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS
• Packaging: 1 kg, 5 kg, 25 kg drums

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