Citrulline Malate

Synonyms: L-Citrulline DL-Malate, Citrulline Malate 2:1, L-Citrulline malate

Citrulline Malate has become a go-to ingredient for formulators targeting nitric oxide support and athletic endurance. Its popularity stems from a simple fact: it delivers more usable L-citrulline to the bloodstream than L-citrulline alone, thanks to the malate component that feeds the Krebs cycle. Sports nutrition brands, pre-workout manufacturers, and clinical nutrition companies have all adopted it as a core active.

Chemically, it is a 1:1 salt of L-citrulline and DL-malic acid, though commercial grades often use a 2:1 ratio (two citrulline to one malate) to maximize the citrulline payload. L-Citrulline itself is a non-protein amino acid first isolated from watermelon, while malic acid is a dicarboxylic acid found in apples and other fruits. The combination is not just additive—malate replenishes tricarboxylic acid cycle intermediates, which can enhance energy production during exercise.

LyvBio supplies Citrulline Malate in a highly purified, crystalline form standardized to ≥98% assay by HPLC. Our material is manufactured via enzymatic conversion and salt formation, followed by crystallization and drying. It is non-GMO, allergen-free, and suitable for vegan and vegetarian formulations.

Product Overview & Composition

Citrulline Malate consists of L-citrulline and DL-malic acid in a defined molar ratio. The most common commercial form is 2:1 (L-citrulline:DL-malic acid), which provides approximately 65% L-citrulline by weight. This ratio is favored because it allows for higher citrulline dosing without exceeding label claims or causing gastrointestinal discomfort.

The malate portion is not a filler—it plays an active role in cellular energy metabolism. Malate is a key intermediate in the malate-aspartate shuttle and the Krebs cycle, helping to sustain ATP production under anaerobic conditions. Together, the two components work synergistically to support nitric oxide synthesis, ammonia clearance, and muscular endurance.

Key Applications

• Sports nutrition: Pre-workout powders, intra-workout drinks, and recovery formulas for endurance and strength athletes.
• Clinical nutrition: Used in medical foods for conditions involving impaired ammonia detoxification or muscle wasting.
• Functional beverages: Ready-to-drink energy and hydration products seeking a non-stimulant performance boost.
• Dietary supplements: Capsules and tablets targeting vascular health and exercise performance.
• Research: Studied for its effects on nitric oxide bioavailability, exercise capacity, and protein metabolism.

Quality & Standards

Packaging & Supply

• Packaging: 25 kg fiber drums with double polyethylene liners, or customized packaging upon request.
• MOQ: 25 kg (1 drum).
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, and nutritional statements available.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com