Temozolomide
| Tham số | Thông số kỹ thuật |
|---|---|
| Tên sản phẩm | Temozolomide |
| Số CAS | 85622-93-1 |
| Công thức phân tử | C6H6N6O2 |
| Trọng lượng phân tử | 194.15 g/mol |
| Hình thức | Bột tinh thể màu trắng đến trắng ngà |
| Phương pháp phân tích (HPLC) | ≥99.0% |
| Độ hòa tan | Slightly soluble in water, soluble in DMSO |
| Gói | 25 kg fiber drum, double PE bag inside |
Cần trợ giúp? Liên hệ với đội ngũ của chúng tôi
Từ đồng nghĩa: Temozolomide, 85622-93-1, Temodar, Temodal, SCH 52365, 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
Temozolomide is an oral alkylating agent that has become a standard of care in neuro-oncology. It is a synthetic imidazotetrazine derivative that undergoes spontaneous hydrolysis at physiological pH to generate the active metabolite 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC), which methylates DNA at the O6 position of guanine, leading to cytotoxicity. Since its approval in the late 1990s, it has been widely used in the treatment of glioblastoma multiforme and anaplastic astrocytoma.
Chemically, temozolomide is a small molecule with a molecular weight of 194.15 g/mol. It is a white to off-white crystalline powder, slightly soluble in water but freely soluble in dimethyl sulfoxide. Its lipophilic nature allows it to cross the blood-brain barrier, a critical property for treating central nervous system tumors. The drug is typically synthesized through a multi-step process starting from 5-aminoimidazole-4-carboxamide, and its purity is critical for both safety and efficacy.
As a generic API, temozolomide is produced under strict cGMP conditions. It is available in various polymorphic forms, with the most stable form being routinely manufactured. The product is standardized to ≥99.0% purity by HPLC, and each batch is tested for residual solvents, heavy metals, and microbial contamination to meet pharmacopeial requirements. It is primarily supplied to generic drug manufacturers and research institutions for the production of oral capsules and for clinical studies.
| Test Item | Thông số kỹ thuật |
|---|---|
| Xác định | IR, HPLC retention time conforms to standard |
| Mất mát khi sấy khô | ≤0.5% |
| Hàm lượng tro sau khi đốt | ≤0.1% |
| Kim loại nặng | ≤20 ppm |
| Organic Impurities | Any individual ≤0.1%, total ≤0.5% |
| Chất dung môi còn lại | Meets ICH Q3C limits |
| Giới hạn vi sinh vật | Total aerobic count ≤1000 CFU/g, yeast & mold ≤100 CFU/g |
Our standard MOQ is 1 kg. For research purposes, we can accommodate smaller quantities; please contact our sales team for details.
For stock items, delivery is typically 3-5 business days after order confirmation.
Yes, a COA is provided with every shipment. Samples are available upon request, typically shipped within 1-2 days.
send us your specification for a quotation.
Room,5-0203, Unit 5, Beiyuanmen Street,Xi'an,Shaanxi,China
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