Pioglitazone
| Tham số | Thông số kỹ thuật |
|---|---|
| Tên sản phẩm | Pioglitazone |
| Số CAS | 111025-46-8 |
| Công thức phân tử | C19H20N2O3S |
| Trọng lượng phân tử | 356.44 g/mol |
| Hình thức | Bột tinh thể màu trắng đến trắng ngà |
| Phương pháp phân tích (HPLC) | ≥99.0% |
| Độ hòa tan | Soluble in DMSO, methanol; practically insoluble in water |
| Gói | 25 kg fiber drum with double polyethylene bags |
Cần trợ giúp? Liên hệ với đội ngũ của chúng tôi
Từ đồng nghĩa: Pioglitazone, U-72107A, AD-4833, (±)-5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]-2,4-thiazolidinedione
Pioglitazone is a thiazolidinedione-class antidiabetic agent that has maintained a steady position in the type 2 diabetes market, particularly in combination regimens where insulin sensitization is needed. While newer drug classes have gained attention, pioglitazone remains relevant for its well-characterized efficacy, oral bioavailability, and cost-effectiveness in generic formulations.
Chemically, pioglitazone is a synthetic compound with the molecular formula C19H20N2O3S and a molecular weight of 356.44 g/mol. It acts as a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, improving insulin sensitivity in peripheral tissues. The compound is typically produced as the hydrochloride salt for pharmaceutical use, though the free base is also available for research and formulation development.
Our pioglitazone is manufactured under strict cGMP conditions and standardized to ≥99.0% purity by HPLC. It is supplied as a white to off-white crystalline powder, soluble in organic solvents like DMSO and methanol but practically insoluble in water. This profile makes it suitable for oral solid dosage forms and a range of preclinical research applications.
Pioglitazone is a member of the thiazolidinedione class, structurally characterized by a 2,4-thiazolidinedione ring linked to a pyridine-ethyl-benzyl moiety. The active pharmaceutical ingredient (API) is often used as the hydrochloride salt to enhance stability and solubility. The free base form is also available for specific research and formulation needs.
The compound is synthesized through a multi-step process that yields high-purity material suitable for pharmaceutical manufacturing. Our production follows ICH guidelines, ensuring consistent quality and regulatory compliance.
| Test Item | Thông số kỹ thuật |
|---|---|
| Xác định | IR, HPLC retention time conforms to standard |
| Mất mát khi sấy khô | ≤0.5% |
| Kim loại nặng | ≤20 ppm |
| Giới hạn vi sinh vật | Total aerobic count ≤1000 CFU/g; yeast and mold ≤100 CFU/g; absence of E. coli and Salmonella |
| Organic Impurities | Any individual impurity ≤0.1%; total impurities ≤0.5% |
| Hàm lượng tro sau khi đốt | ≤0.1% |
We offer flexible MOQs: 1 kg for trial orders and 25 kg for commercial quantities. Larger volumes can be accommodated with scheduled deliveries.
For stock items, delivery is typically 3-5 business days after order confirmation. We maintain adequate inventory to ensure prompt shipment.
Yes, a certificate of analysis (COA) is available for each batch. Samples can be provided upon request, usually shipped within 1-2 days.
Standard packaging is 25 kg fiber drums with double polyethylene liners. Custom packaging is available to meet specific requirements.
send us your specification for a quotation.
Room,5-0203, Unit 5, Beiyuanmen Street,Xi'an,Shaanxi,China
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