Meloxicam

Từ đồng nghĩa: Mobic, Metacam, Movalis, UH-AC 62, 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, Meloxicamum

Meloxicam is an oxicam-class nonsteroidal anti-inflammatory drug (NSAID) that acts as a preferential cyclooxygenase-2 (COX-2) inhibitor. Its chemical structure features a 1,2-benzothiazine-3-carboxamide 1,1-dioxide core, with a 4-hydroxy group and a 2-methyl substituent that enable chelation with the active site of COX-2. This structural motif yields a higher affinity for COX-2 over COX-1, reducing gastrointestinal irritation compared to non-selective NSAIDs. The drug is widely used for its analgesic, anti-inflammatory, and antipyretic properties in both human and veterinary medicine.

Meloxicam is available in various dosage forms, including oral tablets, suspensions, and injectable solutions. It is indicated for the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis in humans, and for the control of pain and inflammation in animals, particularly dogs and cats. The compound is practically insoluble in water but soluble in organic solvents such as dimethylformamide. Its therapeutic efficacy and safety profile have made it a staple in pain management protocols worldwide.

Cấu trúc và tính chất hóa học

Meloxicam belongs to the oxicam family, characterized by a 1,2-benzothiazine ring system. The presence of the 4-hydroxy group allows for keto-enol tautomerism, which is crucial for its binding to the COX-2 enzyme. The enolic form chelates with the active site iron, while the 2-methyl group enhances lipophilicity, facilitating membrane penetration. Meloxicam is a weak acid with a pKa of approximately 4.2, and its solubility is pH-dependent. It is stable under normal storage conditions but should be protected from light and moisture.

Cơ chế tác dụng

• COX-2 inhibition: Meloxicam preferentially inhibits COX-2, reducing the production of prostaglandins that mediate pain and inflammation, while sparing COX-1 to some extent, which helps maintain gastric mucosal integrity.
• Anti-inflammatory effects: By blocking COX-2, meloxicam decreases prostaglandin synthesis at sites of inflammation, alleviating swelling, pain, and fever.
• Analgesic activity: Reduced prostaglandin levels in the central nervous system contribute to its analgesic effects.
• Antipyretic action: Inhibition of COX-2 in the hypothalamus lowers fever by decreasing prostaglandin E2 production.

Quality Specifications (QC Tests)

Cung ứng và Tài liệu

• Công suất: 5 metric tons per month
• Thời gian thực hiện: 3-5 business days (stock items)
• Tài liệu hướng dẫn: COA, MSDS, TDS sẽ được cung cấp theo yêu cầu
• Bao bì: 25 kg fiber drums with double polyethylene liners, or as per customer requirements

Các câu hỏi thường gặp

What is the minimum order quantity (MOQ)?

Our standard MOQ is 25 kg, but we can accommodate smaller trial orders. Please contact us for details.

What is the delivery time?

For stock items, delivery is typically 3-5 business days after order confirmation.

Can you provide a COA and samples?

Yes, we provide a COA for each batch and can send samples for evaluation. Sample delivery usually takes 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.