Escitalopram Oxalate

Từ đồng nghĩa: (S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile oxalate, S-Citalopram oxalate, Cipralex, Lexapro, Seroplex, Entact

Escitalopram oxalate is the oxalate salt of the S-enantiomer of citalopram, a selective serotonin reuptake inhibitor (SSRI). Its structure features a bicyclic isobenzofuran core with a 4-fluorophenyl substituent and a dimethylaminopropyl side chain, which confers high affinity and selectivity for the serotonin transporter (SERT).

As a second-generation antidepressant, escitalopram is widely prescribed for major depressive disorder and generalized anxiety disorder. The oxalate salt enhances aqueous solubility and stability, making it suitable for oral solid dosage forms. It is typically manufactured under cGMP conditions and meets pharmacopeial standards (USP/EP).

In research and pharmaceutical development, escitalopram oxalate serves as a reference standard and active pharmaceutical ingredient (API) for studying serotonin reuptake inhibition, neuropharmacology, and antidepressant efficacy.

Cấu trúc và tính chất hóa học

Escitalopram oxalate is a white to off-white crystalline powder, freely soluble in methanol and water, with a molecular weight of 414.43 g/mol. It is the oxalate salt form, which improves solubility compared to the free base. The compound is optically active, with the S-enantiomer being the therapeutically active form.

Cơ chế tác dụng

• Serotonin transporter inhibition: Escitalopram binds with high affinity to the serotonin transporter (SERT), blocking reuptake of serotonin into presynaptic neurons.
• Increased serotonergic neurotransmission: This leads to elevated extracellular serotonin levels, enhancing serotonergic signaling in the CNS.
• Minimal effect on norepinephrine and dopamine: Unlike some other antidepressants, escitalopram has little effect on norepinephrine and dopamine reuptake, contributing to its favorable side effect profile.
• Allosteric modulation: The S-enantiomer also interacts with an allosteric site on SERT, potentially enhancing its inhibitory effect.

Tiêu chuẩn chất lượng

Cung ứng và Tài liệu

• Công suất: 5 MT per year
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• Tài liệu hướng dẫn: COA, MSDS, TDS, cGMP, DMF available upon request
• Bao bì: 1 kg, 5 kg, 25 kg fiber drums with double polyethylene liners

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