Mebendazole

Từ đồng nghĩa: Methyl 5-benzoyl-2-benzimidazolecarbamate, 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester, R 17635, Vermox, Ovex, Antiox, Telmin

Mebendazole has been a workhorse anthelmintic for decades, and demand remains steady across both human and veterinary markets. Generic manufacturers, contract formulators, and veterinary product developers regularly source the API in bulk, drawn by its well-characterized safety profile, broad spectrum of activity, and cost-effectiveness compared to newer alternatives. While newer drugs have entered the parasiticide space, mebendazole continues to hold its ground in deworming programs, especially in regions where soil-transmitted helminth infections are endemic.

Chemically, mebendazole is a synthetic benzimidazole carbamate, structurally related to flubendazole and fenbendazole. It was developed in the early 1970s by Janssen Pharmaceutica and has since been included in the WHO Model List of Essential Medicines. The molecule acts by binding to β-tubulin, disrupting microtubule assembly in parasitic helminths, which leads to impaired glucose uptake and eventual parasite death. Its poor aqueous solubility is a known challenge, and formulators often rely on micronization or amorphous solid dispersion techniques to improve bioavailability.

LyvBio supplies mebendazole with a minimum assay of 98.5% (HPLC), complying with EP, USP, and BP monographs. Each batch is tested for residual solvents, heavy metals, and microbial limits before release. The material is manufactured under cGMP conditions and comes with full regulatory documentation, making it suitable for generic drug filings and veterinary product registrations.

Product Overview & Composition

Mebendazole is a white to off-white crystalline powder, practically insoluble in water but soluble in formic acid. It is a low-dose, high-potency API, typically formulated into 100 mg or 500 mg chewable tablets, suspensions, or veterinary pastes. The compound is stable under normal storage conditions but should be protected from light and moisture.

As a benzimidazole, mebendazole shares a common structural motif with other anthelmintics in the same class. Its activity spectrum covers common intestinal nematodes such as Ascaris lumbricoides, Trichuris trichiura, hookworms, and Enterobius vermicularis. In veterinary medicine, it is used against a range of gastrointestinal parasites in livestock and companion animals.

Applications & Product Lines

• Human anthelmintic tablets: Mebendazole is formulated into chewable tablets (100 mg, 500 mg) for treating pinworm, roundworm, whipworm, and hookworm infections.
• Pediatric suspensions: A liquid formulation is often preferred for children, where taste-masking and uniform dosing are critical.
• Veterinary dewormers: Used in paste, bolus, or feed additive forms for horses, cattle, sheep, and swine.
• Combination products: Co-formulated with other anthelmintics to broaden the spectrum of activity.
• Compounding pharmacies: Bulk API is used to prepare customized dosage forms for patients with specific needs.

Quality Control Standards

Bulk Packaging & Supply

• Bao bì: 25 kg fiber drum with double polyethylene liner, or as per customer request.
• MOQ: 25 kg
• Thời gian thực hiện: 3-5 business days (stock items)
• Tài liệu hướng dẫn: COA, MSDS, TDS, and regulatory support available upon request.

Các câu hỏi thường gặp

What is the minimum order quantity (MOQ) for mebendazole?

The MOQ is 25 kg. For smaller quantities, please contact our sales team to discuss your specific requirements.

How long does delivery take?

For stock items, delivery typically takes 3-5 business days from order confirmation.

Can you provide a COA and samples?

Yes, we provide a COA for each batch. Samples are available upon request, and we can ship them within 1-2 days after confirmation.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.