Sodium Valproate

Синонимы: Valproic acid sodium salt, Sodium 2-propylpentanoate, Sodium 2-propylvalerate, Valproate sodium, VPA sodium, Depakene, Epilim, 1069-66-5

Sodium valproate is the sodium salt of valproic acid, a branched short-chain fatty acid. Its simple structure—2-propylpentanoic acid—belies a broad spectrum of pharmacological activity. As a salt, it offers superior aqueous solubility compared to the free acid, making it the preferred form for oral and injectable formulations. The compound is chiral? No, it is achiral, but its metabolite profile includes chiral species. It is a white crystalline powder, stable under normal storage conditions.

Commercially, sodium valproate is produced through several synthetic routes, typically starting from propyl halides or via oxidation of 2-propylpentanol. The sodium salt is obtained by neutralizing valproic acid with sodium hydroxide or sodium carbonate. The resulting product is isolated, purified, and dried to meet pharmacopeial standards. It is available in various grades, including USP, EP, and BP, with assay typically 98.0%–102.0% on the dried basis. Our material is manufactured under cGMP conditions and is suitable for use in antiepileptic and mood-stabilizing drug products.

In the pharmaceutical industry, sodium valproate is a key API for the treatment of epilepsy, bipolar disorder, and migraine prophylaxis. Its mechanism involves multiple pathways, including GABAergic enhancement and modulation of voltage-gated ion channels. With steady global demand, especially in generic formulations, sodium valproate remains a staple in the CNS portfolio. LyvBio supplies high-purity sodium valproate to pharmaceutical manufacturers worldwide, supported by comprehensive documentation and reliable supply chain.

Chemical Structure & Properties

Sodium valproate consists of a valproate anion and a sodium cation. The valproate anion is a branched carboxylic acid with a propyl group on the alpha carbon. This branching is crucial for its anticonvulsant activity. The sodium salt is highly water-soluble, which facilitates formulation into syrups, solutions, and lyophilized powders. It is hygroscopic and should be stored in tightly sealed containers away from moisture. The compound is stable at room temperature but may degrade under extreme pH or heat.

Механизм действия

• GABAergic enhancement: Increases brain levels of gamma-aminobutyric acid (GABA) by inhibiting GABA transaminase and succinic semialdehyde dehydrogenase, thereby enhancing inhibitory neurotransmission.
• Voltage-gated sodium channels: Prolongs the inactivation state of sodium channels, reducing neuronal excitability and propagation of seizures.
• T-type calcium channels: Blocks T-type calcium currents, which may contribute to its efficacy in absence seizures.
• HDAC inhibition: Acts as a histone deacetylase inhibitor, which may underlie its mood-stabilizing and neuroprotective effects.

Quality Specifications

Supply & Documentation

• Capacity: 50 metric tons per year
• Срок выполнения заказа: 3–5 рабочих дней (товары, имеющиеся в наличии)
• Documentation: COA, MSDS, TDS, DMF available upon request
• Packaging: 25 kg fiber drum with double polyethylene liner, or as per customer requirements

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