Need help? Contact our team
Melatonin is a naturally occurring neurohormone that regulates the sleep-wake cycle. For the nutraceutical industry, synthetic melatonin (chemically identical to endogenous) is the standard due to cost-effectiveness and batch consistency.
Industry note: >99% of commercial melatonin is synthetic.
| Receptor | Location | Function |
|---|---|---|
| MT1 | Suprachiasmatic nucleus | Sleep onset, circadian phase shift |
| MT2 | Retina, SCN, blood vessels | REM sleep, vasodilation |
| Parameter | Specification |
|---|---|
| Assay (HPLC) | 99.0–101.0% |
| Melting Point | 116–120°C |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm (Pb, As, Hg, Cd) |
| Related Substances | Single impurity ≤ 0.1%; Total ≤ 0.5% |
| Residual Solvents | Meet USP <467> |
| Form | Melatonin Content | Applications |
|---|---|---|
| Crystalline powder | 99%+ | Capsules, tablets |
| Micronized powder | 99%+ | Fast-dissolve, gummies |
| Timed-release beads | 10–30% | Sustained-release capsules |
| Premix (with excipients) | 0.5–10% | Direct compression |
Packaging: 25 kg fiber drums (bulk) / 1–5 kg foil bags (samples)
LyvBio melatonin
Q: Natural vs. synthetic – what’s the difference?
A: Identical molecular structure. Synthetic is >99% of commercial supply, significantly more cost-effective, and batch-consistent.
Q: Optimal particle size for gummies?
A: Micronized (D90 < 20 µm) ensures homogeneous distribution and no grittiness.
Q: Storage requirements?
A: Light-resistant containers (amber/opaque), room temperature (15–25°C), protected from moisture. 36-month shelf life.
Q: MOQ?
A: Samples: 100g–1kg. Trial: 25 kg. Bulk: Negotiable. Lead time: 3–5 days (samples); 10–15 days (bulk).
USP / Ph.Eur. / JP / CP compliant
Full documentation – COA, MSDS, 36-month stability, Non-GMO, Allergen
Formulation support – Custom blends, immediate/prolonged-release, gummy optimization
Lead time: 10–15 days for bulk orders
📧 Email: info@lyvbio.com
🌐 Website: https://www.lyvbio.com
English English 
Russian
French
Korean